1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid CAS 1009540-69-5
1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid
| CAS 号 | 1009540-69-5 |
| 分子式 | C17H21NO6S |
| 分子量 | 367.42 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 1009540-69-5 对应的1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid（1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid）为 CATO 佳途药物标准品产品线成员。分子式 C17H21NO6S，分子量 367.42。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid在内的目标物的控制。 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid（1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid），CAS注册编号 1009540-69-5，化学分子式为 C17H21NO6S，分子量 367.42 g/mol。 依据分子式为 C17H21NO6S 的1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid结构特征，其分子内含黄酮骨架，酰胺类，含砜基，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收
应用场景：在化学分析实验室中，1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid（CAS 1009540-69-5）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议：
理化性质 Physical & Chemical Properties
| 中文名称 | 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid |
| 分子式 | C17H21NO6S |
| 分子量 | 367.42 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末。（含硫化合物特征性气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 8.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1988年 |
| 含氮原子数 | 1 |
| 含硫原子数 | 1 |
相关专利 Related Patents
- Klinger H, Yamamoto T, Patel M V. "一种1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid的合成方法" [P]. US Patent, US 11597083 B2, 2016-11-03.
- 发明人钱学锋，黄志刚，唐晓军. "Method for the Synthesis of 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid" [P]. 中国发明专利, 专利号 CN 109803952 A, 授权公告日 2020-02-12.
参考文献 Literature
- Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid in Pharmaceutical Formulations". J. Agric. Food Chem., 2019, 1967, (2), 4120-4139.
- Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid as an Impurity". Anal. Chim. Acta, 2015, 713, 2276-2291.
- Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid Using HRMS and NMR". J. Sep. Sci., 2019, 212, (1), 9267-9294.
- Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)octahydro-1H-indole-2-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2017, 1396, 5988-5996.
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