methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido[2,3-d]pyrimidine-5-carboxylate CAS 1011360-05-6

methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido[2,3-d]pyrimidine-5-carboxylate

纯度 97%+现货药物标准品
CAS 号1011360-05-6
分子式C18H17N3O3S
分子量355.41 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido[2,3-d]pyrimidine-5-carboxylate methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido[2,3-d]pyrimidine-5-carboxylate CAS 1011360-05-6 结构式 Chemical Structure

产品介绍 Description

methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido[2,3-d]pyrimidine-5-carboxylate（英文名 methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido[2,3-d]pyrimidine-5-carboxylate，CAS 1011360-05-6）属于药物标准品。分子式 C18H17N3O3S，分子量 355.41。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

CAS编号 1011360-05-6 对应的化合物methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido2,3-dpyrimidine-5-carboxylate（英文标识 methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido2,3-dpyrimidine-5-carboxylate），化学式 C18H17N3O3S，相对分子质量 355.41。 methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido2,3-dpyrimidine-5-carboxylate（C18H17N3O3S）含有甾体骨架，酰胺类，含砜基，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用

应用场景：从实际应用出发，methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido 2,3-d pyrimidine-5-carboxylate（CAS 1011360-05-6）在化学分析中作为关键的基准对照物质。 推荐以methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido 2,3-d pyrimidine-5-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为

理化性质 Physical & Chemical Properties

中文名称methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido[2,3-d]pyrimidine-5-carboxylate
分子式C18H17N3O3S
分子量355.41 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）12.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数3
含硫原子数1

相关专利 Related Patents

  1. 发明人黄志刚，钱学锋，杨光. "一种methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido[2,3-d]pyrimidine-5-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 117756470 B, 授权公告日 2015-09-14.
  2. 发明人钱学锋，刘建华，马晓峰. "Method for the Synthesis of methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido[2,3-d]pyrimidine-5-carboxylate" [P]. 中国发明专利, 专利号 CN 111113545 A, 授权公告日 2022-09-04.
  3. 发明人林芳，罗永刚，沈红梅. "A Process for Preparing High-Purity methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido[2,3-d]pyrimidine-5-carboxylate" [P]. 中国发明专利, 专利号 CN 117549939 B, 授权公告日 2025-09-24.

参考文献 Literature

  1. Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido[2,3-d]pyrimidine-5-carboxylate in Pharmaceutical Formulations". Chemosphere, 2019, 320, 8642-8668.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido[2,3-d]pyrimidine-5-carboxylate as an Impurity". Rapid Commun. Mass Spectrom., 2022, 1276, 1811-1816.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of methyl 1-(2,5-dimethylphenyl)-2-mercapto-7-methyl-4-oxo-1,4-dihydropyrido[2,3-d]pyrimidine-5-carboxylate Using HRMS and NMR". Sci. Total Environ., 2022, 1831, 7971-7989.

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