methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate CAS 1011399-25-9

methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

纯度 97%+现货药物标准品
CAS 号1011399-25-9
分子式C20H21N3O4
分子量367.40 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate CAS 1011399-25-9 结构式 Chemical Structure

产品介绍 Description

CAS 1011399-25-9 对应的methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate（methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C20H21N3O4，分子量 367.40。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo3,4-bpyridine-4-carboxylate在内的目标物的控制。 CAS编号 1011399-25-9 对应的化合物methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo3,4-bpyridine-4-carboxylate（英文标识 methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo3,4-bpyridine-4-carboxylate），化学式 C20H21N3O4，相对分子质量 367.40。 methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo3,4-bpyridine-4-carboxyla

应用场景：在化学分析实验室中，methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo 3,4-b pyridine-4-carboxylate（CAS 1011399-25-9）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo 3,4-b pyridine-4-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:

理化性质 Physical & Chemical Properties

中文名称methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
分子式C20H21N3O4
分子量367.40 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）12.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数3

相关专利 Related Patents

  1. 发明人杨光，胡光，王建平. "一种methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 109339431 A, 授权公告日 2015-06-17.
  2. 发明人林芳，马晓峰，郭海燕. "Method for the Synthesis of methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate" [P]. 中国发明专利, 专利号 CN 113132121 B, 授权公告日 2024-08-06.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate in Pharmaceutical Formulations". Chemosphere, 2013, 98, (10), 8057-8062.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate as an Impurity". Chromatographia, 2016, 1304, 7325-7340.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate Using HRMS and NMR". J. Chromatogr. A, 2018, 2303, 4540-4548.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate methyl 1-(2-ethoxy-2-oxoethyl)-3-methyl-6-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2023, 1850, (1), 6047-6068.

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