4-[(2-methoxyphenyl)methyl]-1-{[(4-methylphenyl)methyl]sulfanyl}-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one CAS 1012760-54-1

4-[(2-methoxyphenyl)methyl]-1-{[(4-methylphenyl)methyl]sulfanyl}-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one

纯度 97%+现货药物标准品
CAS 号1012760-54-1
分子式C25H22N4O2S
分子量442.53 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-[(2-methoxyphenyl)methyl]-1-{[(4-methylphenyl)methyl]sulfanyl}-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one 4-[(2-methoxyphenyl)methyl]-1-{[(4-methylphenyl)methyl]sulfanyl}-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one CAS 1012760-54-1 结构式 Chemical Structure

产品介绍 Description

4-[(2-methoxyphenyl)methyl]-1-{[(4-methylphenyl)methyl]sulfanyl}-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one（英文名 4-[(2-methoxyphenyl)methyl]-1-{[(4-methylphenyl)methyl]sulfanyl}-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one，CAS 1012760-54-1）属于药物标准品。分子式 C25H22N4O2S，分子量 442.53。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 4-(2-methoxyphenyl)methyl-1-{(4-methylphenyl)methylsulfanyl}-4H,5H-1,2,4triazolo4,3-aquinazolin-5-one（4-(2-methoxyphenyl)methyl-1-{(4-methylphenyl)methylsulfanyl}-4H,5H-1,2,4triazolo4,3-aquinazolin-5-one），CAS注册编号 1012760-54-1，化学分子式为 C25H22N4O2S，分子量 442.53 g/mol。 受分子结构中甾体骨架，酰胺类，含砜基，含羟基，含醚键的影响，4-(2-methoxyphenyl)methyl-1-{(4-methylphenyl)methylsulfanyl}-4H,5H-1,2,4triazolo4,3-aquinazolin-5-one表现为淡黄色至黄色

应用场景：针对化学分析用途，4- (2-methoxyphenyl)methyl -1-{ (4-methylphenyl)methyl sulfanyl}-4H,5H- 1,2,4 triazolo 4,3-a quinazolin-5-one（4- (2-methoxyphenyl)methyl -1-{ (4-methylphenyl)methyl sulfanyl}-4H,5H- 1,2,4 triazolo 4,3-a quinazolin-5-one）是具有明确定量溯源的认证级对照品。 推荐以4- (2-methoxyphenyl)methyl -1-{ (4-methylphenyl)m

理化性质 Physical & Chemical Properties

中文名称4-[(2-methoxyphenyl)methyl]-1-{[(4-methylphenyl)methyl]sulfanyl}-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
分子式C25H22N4O2S
分子量442.53 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）17.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数4
含硫原子数1

相关专利 Related Patents

  1. 发明人张德明，沈红梅，周伟. "一种4-[(2-methoxyphenyl)methyl]-1-{[(4-methylphenyl)methyl]sulfanyl}-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one的合成方法" [P]. 中国发明专利, 专利号 CN 108724757 B, 授权公告日 2016-09-21.
  2. Williams B T, Stevens L M, Brown S R. "Method for the Synthesis of 4-[(2-methoxyphenyl)methyl]-1-{[(4-methylphenyl)methyl]sulfanyl}-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one" [P]. US Patent, US 9132724 B2, 2016-01-19.
  3. 发明人钱学锋，刘建华，韩伟. "A Process for Preparing High-Purity 4-[(2-methoxyphenyl)methyl]-1-{[(4-methylphenyl)methyl]sulfanyl}-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one" [P]. 中国发明专利, 专利号 CN 115382084 A, 授权公告日 2017-06-20.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 4-[(2-methoxyphenyl)methyl]-1-{[(4-methylphenyl)methyl]sulfanyl}-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one in Pharmaceutical Formulations". Anal. Methods, 2012, 2148, 6043-6070.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-[(2-methoxyphenyl)methyl]-1-{[(4-methylphenyl)methyl]sulfanyl}-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one as an Impurity". Rapid Commun. Mass Spectrom., 2014, 560, 9304-9324.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of 4-[(2-methoxyphenyl)methyl]-1-{[(4-methylphenyl)methyl]sulfanyl}-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one Using HRMS and NMR". Food Chem., 2022, 981, 5196-5214.

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