[3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid CAS 1018142-71-6

[3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid

纯度 97%+现货药物标准品
CAS 号1018142-71-6
分子式C12H11F2N3O3
分子量283.23 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid CAS 1018142-71-6 结构式 Chemical Structure

产品介绍 Description

CAS 1018142-71-6 对应的[3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid（[3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid）为 CATO 佳途药物标准品产品线成员。分子式 C12H11F2N3O3，分子量 283.23。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo3,4-bpyridin-1-ylacetic acid的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 1018142-71-6 对应的化合物3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo3,4-bpyridin-1-ylacetic acid（英文标识 3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo3,4-bpyridin-1-ylacetic acid），化学式 C12H11F2N3O3，相对分子质量 283.23。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代的影响，3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihy

应用场景： 3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo 3,4-b pyridin-1-yl acetic acid（ 3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo 3,4-b pyridin-1-yl acetic acid）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以 3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo 3,4-b pyridin-1

理化性质 Physical & Chemical Properties

中文名称[3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid
分子式C12H11F2N3O3
分子量283.23 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. 发明人马晓峰，张德明，李文辉. "一种[3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid的合成方法" [P]. 中国发明专利, 专利号 CN 112202594 B, 授权公告日 2023-06-14.
  2. 发明人罗永刚，徐明华，胡光. "Method for the Synthesis of [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid" [P]. 中国发明专利, 专利号 CN 108390529 B, 授权公告日 2018-07-17.
  3. 发明人朱建伟，沈红梅，王建平. "A Process for Preparing High-Purity [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid" [P]. 中国发明专利, 专利号 CN 113724618 B, 授权公告日 2020-07-23.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid in Pharmaceutical Formulations". Chemosphere, 2014, 2039, (9), 5265-5289.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid as an Impurity". Talanta, 2014, 1784, (3), 6732-6744.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2011, 1790, 974-985.
  4. Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2025, 222, 2896-2902.

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