[4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid CAS 1018150-76-9

[4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid

纯度 97%+现货药物标准品
CAS 号1018150-76-9
分子式C10H9F2N3O3
分子量257.19 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid [4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid CAS 1018150-76-9 结构式 Chemical Structure

产品介绍 Description

[4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid（英文名 [4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid，CAS 1018150-76-9）属于药物标准品。分子式 C10H9F2N3O3，分子量 257.19。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo3,4-bpyridin-1-ylacetic acid的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 1018150-76-9 对应的化合物4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo3,4-bpyridin-1-ylacetic acid（英文标识 4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo3,4-bpyridin-1-ylacetic acid），化学式 C10H9F2N3O3，相对分子质量 257.19。 从化学结构特征来看，4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo3,4-bpyridin-1-ylacetic ac

应用场景： 4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo 3,4-b pyridin-1-yl acetic acid（ 4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo 3,4-b pyridin-1-yl acetic acid，CAS 1018150-76-9）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以 4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo 3,4-b pyridin-1

理化性质 Physical & Chemical Properties

中文名称[4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid
分子式C10H9F2N3O3
分子量257.19 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. Johnson M A, Lee S K, Klinger H. "一种[4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid的合成方法" [P]. US Patent, US 9692892 B2, 2015-07-05.
  2. Roberts E F, Mueller T, Thompson G K. "Method for the Synthesis of [4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid" [P]. US Patent, US 9611432 B2, 2015-10-19.
  3. 发明人郭海燕，钱学锋，周伟. "A Process for Preparing High-Purity [4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid" [P]. 中国发明专利, 专利号 CN 117541834 A, 授权公告日 2016-07-19.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of [4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2018, 1580, 2689-2706.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of [4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid as an Impurity". Phytochemistry, 2020, 2091, (5), 9172-9188.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of [4-(difluoromethyl)-3-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid Using HRMS and NMR". Chemosphere, 2018, 871, 6045-6064.

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