3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine- 5-carboxylic acid CAS 1031967-08-4

3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine- 5-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1031967-08-4
分子式C12H14N2O4
分子量250.25 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine- 5-carboxylic acid 3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine- 5-carboxylic acid CAS 1031967-08-4 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine- 5-carboxylic acid（3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine- 5-carboxylic acid，CAS 1031967-08-4），分子式 C12H14N2O4，分子量 250.25。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

与同类药物标准品相比，3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro2,3-dpyrimidine- 5-carboxylic acid的分子量为250.25 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 1031967-08-4 对应的化合物3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro2,3-dpyrimidine- 5-carboxylic acid（英文标识 3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro2,3-dpyrimidine- 5-carboxylic acid），化学式 C12H14N2O4，相对分子质量 250.25。 受分子结构中氨基酸衍生物，酰胺类，含羟基，含醚键的影响，3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro2,3-dpyrimidine- 5-carboxylic acid表现为类白色至淡黄色结晶性粉末。其固体形态的物理化学属性——包括250.25 g/

应用场景：针对化学分析用途，3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro 2,3-d pyrimidine- 5-carboxylic acid（3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro 2,3-d pyrimidine- 5-carboxylic acid）是具有明确定量溯源的认证级对照品。 推荐以3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro 2,3-d pyrimidine- 5-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙

理化性质 Physical & Chemical Properties

中文名称3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine- 5-carboxylic acid
分子式C12H14N2O4
分子量250.25 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数2

相关专利 Related Patents

  1. 发明人周伟，林芳，陈志强. "一种3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine- 5-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 117186209 A, 授权公告日 2019-02-16.
  2. Johnson M A, Anderson J P, Williams B T. "Method for the Synthesis of 3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine- 5-carboxylic acid" [P]. US Patent, US 11570536 B2, 2021-09-09.
  3. 发明人冯建国，赵玉洁，林芳. "A Process for Preparing High-Purity 3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine- 5-carboxylic acid" [P]. 中国发明专利, 专利号 CN 110636214 A, 授权公告日 2021-11-15.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine- 5-carboxylic acid in Pharmaceutical Formulations". J. Sep. Sci., 2014, 1411, (1), 427-430.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine- 5-carboxylic acid as an Impurity". J. Agric. Food Chem., 2020, 1751, (9), 7646-7658.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine- 5-carboxylic acid Using HRMS and NMR". J. Chromatogr. A, 2021, 1893, 7739-7745.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate 3-isobutyl-6-methyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine- 5-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Talanta, 2011, 639, 7798-7809.

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