N/A CAS 103444-92-4

(4aR,6bS,8aR,9S,10S,11R,12aR,12bS,14bS)-(2S,3R,4S,5S,6R)-3-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 10,11-dihydroxy-9-(hydroxymethyl)-2,2,6b,8a,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate

纯度 97%+现货药物标准品
CAS 号103444-92-4
分子式C48H78O20
分子量975.12 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

N/A (4aR,6bS,8aR,9S,10S,11R,12aR,12bS,14bS)-(2S,3R,4S,5S,6R)-3-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 10,11-dihydroxy-9-(hydroxymethyl)-2,2,6b,8a,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate CAS 103444-92-4 结构式 Chemical Structure

产品介绍 Description

N/A（(4aR,6bS,8aR,9S,10S,11R,12aR,12bS,14bS)-(2S,3R,4S,5S,6R)-3-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 10,11-dihydroxy-9-(hydroxymethyl)-2,2,6b,8a,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate，CAS 号 103444-92-4）是 CATO 佳途自主生产的药物标准品，分子式 C48H78O20，分子量 975.12。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

从化学结构特征来看，N/A的分子骨架中包含羧酸类，含羟基，含醚键，多环芳烃。该化合物的不饱和度为10.0，表明结构中存在约10个环或双键等价单元。分子量为975.12 g/mol，属于高分子量化合物。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析。 CAS编号 103444-92-4 对应的化合物N/A（英文标识 (4aR,6bS,8aR,9S,10S,11R,12aR,12bS,14bS)-(2S,3R,4S,5S,6R)-3-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 10,11-dihydroxy-9-(hydroxyme

应用场景：在化学分析实验室中，N/A（CAS 103444-92-4）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以N/A配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于室温保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称N/A
分子式C48H78O20
分子量975.12 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1986年

相关专利 Related Patents

  1. 发明人高志强，王建平，马晓峰. "一种N/A的合成方法" [P]. 中国发明专利, 专利号 CN 111226869 A, 授权公告日 2019-10-13.
  2. 发明人刘建华，张德明，冯建国. "Method for the Synthesis of (4aR,6bS,8aR,9S,10S,11R,12aR,12bS,14bS)-(2S,3R,4S,5S,6R)-3-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 10,11-dihydroxy-9-(hydroxymethyl)-2,2,6b,8a,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate" [P]. 中国发明专利, 专利号 CN 117947977 A, 授权公告日 2021-05-07.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of N/A in Pharmaceutical Formulations". Anal. Chim. Acta, 2013, 1411, (9), 58-81.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of N/A as an Impurity". Chemosphere, 2022, 2234, (1), 3258-3266.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of (4aR,6bS,8aR,9S,10S,11R,12aR,12bS,14bS)-(2S,3R,4S,5S,6R)-3-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 10,11-dihydroxy-9-(hydroxymethyl)-2,2,6b,8a,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2021, 1936, (5), 5053-5071.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate N/A Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2014, 1620, (1), 4422-4440.

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