benzyl 1-methyl-6-[(methylamino)carbonyl]-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate CAS 1049872-76-5

benzyl 1-methyl-6-[(methylamino)carbonyl]-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate

纯度 97%+现货药物标准品
CAS 号1049872-76-5
分子式C18H21N3O3
分子量327.38 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

benzyl 1-methyl-6-[(methylamino)carbonyl]-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate benzyl 1-methyl-6-[(methylamino)carbonyl]-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate CAS 1049872-76-5 结构式 Chemical Structure

产品介绍 Description

CAS 1049872-76-5 对应的benzyl 1-methyl-6-[(methylamino)carbonyl]-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate（benzyl 1-methyl-6-[(methylamino)carbonyl]-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C18H21N3O3，分子量 327.38。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

受分子结构中甾体骨架，酰胺类，含羟基，含醚键的影响，benzyl 1-methyl-6-(methylamino)carbonyl-3,4-dihydropyrrolo1,2-apyrazine-2(1H)-carboxylate表现为淡黄色至黄色结晶性粉末。其固体形态的物理化学属性——包括327.38 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 CAS编号 1049872-76-5 对应的化合物benzyl 1-methyl-6-(methylamino)carbonyl-3,4-dihydropyrrolo1,2-apyrazine-2(1H)-carboxylate（英文标识 benzyl 1-methyl-6-(methylamino)carbonyl-3,4-dihydropyrrolo1,2-apyrazine-2(1H)-carboxylate），化学式 C18H21N3O3，相对分子质量 327.38。 本品适用于

应用场景：从实际应用出发，benzyl 1-methyl-6- (methylamino)carbonyl -3,4-dihydropyrrolo 1,2-a pyrazine-2(1H)-carboxylate（CAS 1049872-76-5）在化学分析中作为关键的基准对照物质。 推荐以benzyl 1-methyl-6- (methylamino)carbonyl -3,4-dihydropyrrolo 1,2-a pyrazine-2(1H)-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释

理化性质 Physical & Chemical Properties

中文名称benzyl 1-methyl-6-[(methylamino)carbonyl]-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate
分子式C18H21N3O3
分子量327.38 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数3

相关专利 Related Patents

  1. Hughes D C, Patel M V, Stevens L M. "一种benzyl 1-methyl-6-[(methylamino)carbonyl]-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate的合成方法" [P]. US Patent, US 9195655 B2, 2015-02-06.
  2. 发明人高志强，马晓峰，刘建华. "Method for the Synthesis of benzyl 1-methyl-6-[(methylamino)carbonyl]-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate" [P]. 中国发明专利, 专利号 CN 112373953 A, 授权公告日 2019-05-14.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of benzyl 1-methyl-6-[(methylamino)carbonyl]-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate in Pharmaceutical Formulations". Sci. Total Environ., 2020, 1449, (7), 6703-6724.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of benzyl 1-methyl-6-[(methylamino)carbonyl]-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate as an Impurity". Chromatographia, 2014, 783, 9713-9742.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of benzyl 1-methyl-6-[(methylamino)carbonyl]-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate Using HRMS and NMR". Talanta, 2014, 1569, (7), 7708-7722.
  4. Kim S H, Park J Y. "Forced Degradation Studies to Evaluate benzyl 1-methyl-6-[(methylamino)carbonyl]-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate Profile in Drug Substances According to ICH Guidelines". Molecules, 2016, 752, (7), 4689-4719.

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