(1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)acetic acid CAS 1087784-33-5

(1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)acetic acid

纯度 97%+现货药物标准品
CAS 号1087784-33-5
分子式C10H11N3O4
分子量237.21 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)acetic acid (1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)acetic acid CAS 1087784-33-5 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品(1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)acetic acid（(1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)acetic acid，CAS 1087784-33-5），分子式 C10H11N3O4，分子量 237.21。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

化学式为 C10H11N3O4 的(1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo3,4-bpyridin-5-yl)acetic acid（(1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo3,4-bpyridin-5-yl)acetic acid），其CAS登记号是 1087784-33-5，分子量为 237.21 g/mol。 从化学结构特征来看，(1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo3,4-bpyridin-5-yl)acetic acid的分子骨架中包含氨基酸衍生物，酰胺类，含羟基，含醚键。该化合物的不饱和度为7.0，表明结构中存在约7个环或双键等价单元。分子量为237.21 g/mol，属于中等分子量化合物。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-V

应用场景：(1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo 3,4-b pyridin-5-yl)acetic acid（(1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo 3,4-b pyridin-5-yl)acetic acid）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以(1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo 3,4-b pyridin-5-yl)acetic acid配制标准系列工作溶液，用

理化性质 Physical & Chemical Properties

中文名称(1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)acetic acid
分子式C10H11N3O4
分子量237.21 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
含氮原子数3

相关专利 Related Patents

  1. 发明人唐晓军，高志强，胡光. "一种(1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)acetic acid的合成方法" [P]. 中国发明专利, 专利号 CN 108879741 A, 授权公告日 2016-05-09.
  2. Sørensen M, Schröder R, Rossi M. "Method for the Synthesis of (1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)acetic acid" [P]. European Patent, EP 3295945 A1, 2017-12-22.
  3. 发明人王建平，郑宇鹏，刘建华. "A Process for Preparing High-Purity (1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)acetic acid" [P]. 中国发明专利, 专利号 CN 108920715 A, 授权公告日 2025-02-24.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of (1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)acetic acid in Pharmaceutical Formulations". Molecules, 2020, 796, 9499-9525.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of (1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)acetic acid as an Impurity". Talanta, 2012, 1881, (8), 4664-4688.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of (1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)acetic acid Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2020, 688, (3), 8740-8761.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate (1,4-dimethyl-3,6-dioxo-2,3,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)acetic acid Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2025, 2119, (8), 2539-2559.

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