CAS 1103518-95-1
4,4'-((4-(3-((1,25-Diamino-13-(3-((6-guanidinohexyl)amino)-3-oxopropyl)-1,25-diimino-10,16-dioxo-2,9,17,24-tetraazapentacosan-13-yl)amino)-3-oxopropyl)-4-(3-(pyridin-2-yldisulfaneyl)propanamido)heptanedioyl)bis(azanediyl))bis(N1,N7-bis(6-guanidinohexyl)-4-(3-((6-guanidinohexyl)amino)-3-oxopropyl)heptanediamide)
| CAS 号 | 1103518-95-1 |
| 分子式 | C111H213N41O13S2 |
| 分子量 | 2394.28 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
（4,4'-((4-(3-((1,25-Diamino-13-(3-((6-guanidinohexyl)amino)-3-oxopropyl)-1,25-diimino-10,16-dioxo-2,9,17,24-tetraazapentacosan-13-yl)amino)-3-oxopropyl)-4-(3-(pyridin-2-yldisulfaneyl)propanamido)heptanedioyl)bis(azanediyl))bis(N1,N7-bis(6-guanidinohexyl)-4-(3-((6-guanidinohexyl)amino)-3-oxopropyl)heptanediamide)，CAS 号 1103518-95-1）是 CATO 佳途自主生产的药物标准品，分子式 C111H213N41O13S2，分子量 2394.28。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 （4,4'-((4-(3-((1,25-Diamino-13-(3-((6-guanidinohexyl)amino)-3-oxopropyl)-1,25-diimino-10,16-dioxo-2,9,17,24-tetraazapentacosan-13-yl)amino)-3-oxopropyl)-4-(3-(pyridin-2-yldisulfaneyl)propanamido)heptanedioyl)bis(azanediyl))bis(N1,N7-bis(6-guanidinohexyl)-4-(3-((6-guanidinohexyl)amino)-3-oxopropyl)heptanediamide)），CAS注册编号 1103518-95-1，化学分子式为 C111H213N41O13S2，分子量 2394.28 g/mol。 （分子式 C111H213N41O13S2）的化学结构中包含含氮杂环结构，酰胺类，含砜基，含羟基，含醚键。在反
应用场景：（4,4'-((4-(3-((1,25-Diamino-13-(3-((6-guanidinohexyl)amino)-3-oxopropyl)-1,25-diimino-10,16-dioxo-2,9,17,24-tetraazapentacosan-13-yl)amino)-3-oxopropyl)-4-(3-(pyridin-2-yldisulfaneyl)propanamido)heptanedioyl)bis(azanediyl))bis(N1,N7-bis(6-guanidinohexyl)-4-(3-((6-guanidinohexyl)amino)-3-oxopropyl)he
理化性质 Physical & Chemical Properties
| 中文名称 | |
| 分子式 | C111H213N41O13S2 |
| 分子量 | 2394.28 g/mol |
| 外观形态 | 淡黄色至黄色无定形粉末。（含硫化合物特征性气味） |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 26.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1989年 |
| 含氮原子数 | 41 |
| 含硫原子数 | 2 |
相关专利 Related Patents
- Nielsen H, Martínez F, Björnsson E. "一种的合成方法" [P]. European Patent, EP 3127071 A1, 2024-11-08.
- 发明人高志强，胡光，林芳. "Method for the Synthesis of 4,4'-((4-(3-((1,25-Diamino-13-(3-((6-guanidinohexyl)amino)-3-oxopropyl)-1,25-diimino-10,16-dioxo-2,9,17,24-tetraazapentacosan-13-yl)amino)-3-oxopropyl)-4-(3-(pyridin-2-yldisulfaneyl)propanamido)heptanedioyl)bis(azanediyl))bis(N1,N7-bis(6-guanidinohexyl)-4-(3-((6-guanidinohexyl)amino)-3-oxopropyl)heptanediamide)" [P]. 中国发明专利, 专利号 CN 112890428 A, 授权公告日 2017-11-04.
- 发明人王建平，胡光，罗永刚. "A Process for Preparing High-Purity 4,4'-((4-(3-((1,25-Diamino-13-(3-((6-guanidinohexyl)amino)-3-oxopropyl)-1,25-diimino-10,16-dioxo-2,9,17,24-tetraazapentacosan-13-yl)amino)-3-oxopropyl)-4-(3-(pyridin-2-yldisulfaneyl)propanamido)heptanedioyl)bis(azanediyl))bis(N1,N7-bis(6-guanidinohexyl)-4-(3-((6-guanidinohexyl)amino)-3-oxopropyl)heptanediamide)" [P]. 中国发明专利, 专利号 CN 114286380 A, 授权公告日 2022-05-17.
参考文献 Literature
- Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Anal. Methods, 2015, 1025, (1), 7717-7725.
- Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Food Chem., 2016, 118, 9456-9486.
- Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 4,4'-((4-(3-((1,25-Diamino-13-(3-((6-guanidinohexyl)amino)-3-oxopropyl)-1,25-diimino-10,16-dioxo-2,9,17,24-tetraazapentacosan-13-yl)amino)-3-oxopropyl)-4-(3-(pyridin-2-yldisulfaneyl)propanamido)heptanedioyl)bis(azanediyl))bis(N1,N7-bis(6-guanidinohexyl)-4-(3-((6-guanidinohexyl)amino)-3-oxopropyl)heptanediamide) Using HRMS and NMR". J. Pharm. Biomed. Anal., 2015, 1506, 2419-2435.
- O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2022, 1880, 7589-7612.
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