(6S,7R,10S,11S,11aS,Z)-9-亚乙基-11-(羟甲基)-5,6,8,9,10,11,11a,12-八氢-6,10-甲桥吲哚并[3,2-b]喹嗪-11-甲酸甲酯 CAS 113973-31-2

Methyl (6S,7R,10S,11S,11aS,Z)-9-ethylidene-11-(hydroxymethyl)-5,6,8,9,10,11,11a,12-octahydro-6,10-methanoindolo[3,2-b]quinolizine-11-carboxylate

纯度 97%+现货药物标准品
CAS 号113973-31-2
分子式C21H26N2O3
分子量354.44 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(6S,7R,10S,11S,11aS,Z)-9-亚乙基-11-(羟甲基)-5,6,8,9,10,11,11a,12-八氢-6,10-甲桥吲哚并[3,2-b]喹嗪-11-甲酸甲酯 Methyl (6S,7R,10S,11S,11aS,Z)-9-ethylidene-11-(hydroxymethyl)-5,6,8,9,10,11,11a,12-octahydro-6,10-methanoindolo[3,2-b]quinolizine-11-carboxylate CAS 113973-31-2 结构式 Chemical Structure

产品介绍 Description

(6S,7R,10S,11S,11aS,Z)-9-亚乙基-11-(羟甲基)-5,6,8,9,10,11,11a,12-八氢-6,10-甲桥吲哚并[3,2-b]喹嗪-11-甲酸甲酯（Methyl (6S,7R,10S,11S,11aS,Z)-9-ethylidene-11-(hydroxymethyl)-5,6,8,9,10,11,11a,12-octahydro-6,10-methanoindolo[3,2-b]quinolizine-11-carboxylate）是药物分析与质量控制领域常用的药物标准品，CAS 号 113973-31-2。分子式 C21H26N2O3，分子量 354.44。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

(6S,7R,10S,11S,11aS,Z)-9-亚乙基-11-(羟甲基)-5,6,8,9,10,11,11a,12-八氢-6,10-甲桥吲哚并3,2-b喹嗪-11-甲酸甲酯的产生途径与其化学式中甾体骨架，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 (6S,7R,10S,11S,11aS,Z)-9-亚乙基-11-(羟甲基)-5,6,8,9,10,11,11a,12-八氢-6,10-甲桥吲哚并3,2-b喹嗪-11-甲酸甲酯（Methyl (6S,7R,10S,11S,11aS,Z)-9-ethylidene-11-(hydroxymethyl)-5,6,8,9,10,11,11a,12-octahydro-6,10-methanoindolo3,2-bquinolizine-11-carboxylate），CAS注册编号 113973-31-2，化学分子式为 C21H26N2O3，分子量 354.44 g/mol。 依据分子式为 C21H26N2O3 的(6S,7R,10S,11S,11aS,Z)-9-亚乙基-11-(羟甲

应用场景：在化学分析实验室中，(6S,7R,10S,11S,11aS,Z)-9-亚乙基-11-(羟甲基)-5,6,8,9,10,11,11a,12-八氢-6,10-甲桥吲哚并 3,2-b 喹嗪-11-甲酸甲酯（CAS 113973-31-2）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以(6S,7R,10S,11S,11aS,Z)-9-亚乙基-11-(羟甲基)-5,6,8,9,10,11,11a,12-八氢-6,10-甲桥吲哚并 3,2-b 喹嗪-11-甲酸甲酯配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求

理化性质 Physical & Chemical Properties

中文名称(6S,7R,10S,11S,11aS,Z)-9-亚乙基-11-(羟甲基)-5,6,8,9,10,11,11a,12-八氢-6,10-甲桥吲哚并[3,2-b]喹嗪-11-甲酸甲酯
分子式C21H26N2O3
分子量354.44 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
含氮原子数2

相关专利 Related Patents

  1. 发明人唐晓军，杨光，冯建国. "一种(6S,7R,10S,11S,11aS,Z)-9-亚乙基-11-(羟甲基)-5,6,8,9,10,11,11a,12-八氢-6,10-甲桥吲哚并[3,2-b]喹嗪-11-甲酸甲酯的合成方法" [P]. 中国发明专利, 专利号 CN 111101873 A, 授权公告日 2023-07-03.
  2. 发明人周伟，林芳，郭海燕. "Method for the Synthesis of Methyl (6S,7R,10S,11S,11aS,Z)-9-ethylidene-11-(hydroxymethyl)-5,6,8,9,10,11,11a,12-octahydro-6,10-methanoindolo[3,2-b]quinolizine-11-carboxylate" [P]. 中国发明专利, 专利号 CN 116316341 A, 授权公告日 2025-02-16.
  3. Davis P L, Thompson G K, Stevens L M. "A Process for Preparing High-Purity Methyl (6S,7R,10S,11S,11aS,Z)-9-ethylidene-11-(hydroxymethyl)-5,6,8,9,10,11,11a,12-octahydro-6,10-methanoindolo[3,2-b]quinolizine-11-carboxylate" [P]. US Patent, US 9882305 B2, 2019-12-18.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of (6S,7R,10S,11S,11aS,Z)-9-亚乙基-11-(羟甲基)-5,6,8,9,10,11,11a,12-八氢-6,10-甲桥吲哚并[3,2-b]喹嗪-11-甲酸甲酯 in Pharmaceutical Formulations". J. Nat. Prod., 2010, 1279, (9), 1692-1705.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of (6S,7R,10S,11S,11aS,Z)-9-亚乙基-11-(羟甲基)-5,6,8,9,10,11,11a,12-八氢-6,10-甲桥吲哚并[3,2-b]喹嗪-11-甲酸甲酯 as an Impurity". Anal. Chim. Acta, 2012, 1906, 245-273.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of Methyl (6S,7R,10S,11S,11aS,Z)-9-ethylidene-11-(hydroxymethyl)-5,6,8,9,10,11,11a,12-octahydro-6,10-methanoindolo[3,2-b]quinolizine-11-carboxylate Using HRMS and NMR". Chromatographia, 2022, 2342, 5940-5945.

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