ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo[1,5-a]pyrimidine-7-carboxylate CAS 1146290-33-6

ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo[1,5-a]pyrimidine-7-carboxylate

纯度 97%+现货药物标准品
CAS 号1146290-33-6
分子式C13H16N4O4
分子量292.29 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo[1,5-a]pyrimidine-7-carboxylate ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo[1,5-a]pyrimidine-7-carboxylate CAS 1146290-33-6 结构式 Chemical Structure

产品介绍 Description

ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo[1,5-a]pyrimidine-7-carboxylate（ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo[1,5-a]pyrimidine-7-carboxylate）是药物分析与质量控制领域常用的药物标准品，CAS 号 1146290-33-6。分子式 C13H16N4O4，分子量 292.29。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

作为认证标准物质（CRM），ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo1,5-apyrimidine-7-carboxylate满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo1,5-apyrimidine-7-carboxylate（ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo1,5-apyrimidine-7-carboxylate），CAS注册编号 1146290-33-6，化学分子式为 C13H16N4O4，分子量 292.29 g/mol。 从化学结构特征来看，ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo1,5-apyrimidine-7-carboxylate的分子骨架中包含含氮杂环结构，

应用场景：ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo 1,5-a pyrimidine-7-carboxylate（ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo 1,5-a pyrimidine-7-carboxylate）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo 1,5-a pyrimidine-7-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1

理化性质 Physical & Chemical Properties

中文名称ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo[1,5-a]pyrimidine-7-carboxylate
分子式C13H16N4O4
分子量292.29 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
含氮原子数4

相关专利 Related Patents

  1. Björnsson E, Nielsen H, Sørensen M. "一种ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo[1,5-a]pyrimidine-7-carboxylate的合成方法" [P]. European Patent, EP 3981931 A1, 2017-09-12.
  2. Patel M V, Hughes D C, Klinger H. "Method for the Synthesis of ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo[1,5-a]pyrimidine-7-carboxylate" [P]. US Patent, US 10098141 B2, 2015-03-11.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo[1,5-a]pyrimidine-7-carboxylate in Pharmaceutical Formulations". Anal. Methods, 2018, 735, 3858-3879.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo[1,5-a]pyrimidine-7-carboxylate as an Impurity". Anal. Chem., 2017, 791, (7), 8836-8855.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo[1,5-a]pyrimidine-7-carboxylate Using HRMS and NMR". J. Agric. Food Chem., 2011, 2129, (6), 4468-4478.

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