2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS 1154741-01-1

2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

纯度 97%+现货药物标准品
CAS 号1154741-01-1
分子式C16H23BO3
分子量274.16 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS 1154741-01-1 结构式 Chemical Structure

产品介绍 Description

2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane（英文名 2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane，CAS 1154741-01-1）属于药物标准品。分子式 C16H23BO3，分子量 274.16。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane在内的目标物的控制。 化学式为 C16H23BO3 的2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane（2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane），其CAS登记号是 1154741-01-1，分子量为 274.16 g/mol。 2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane（C16H23BO3）含有羧酸类，含羟基，含醚键。较高的碳氢比使其脂溶性较好，羧基赋予其一定的酸性特征，这

应用场景：针对化学分析用途，2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane（2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane）是具有明确定量溯源的认证级对照品。 推荐以2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane配制标准系列工作溶

理化性质 Physical & Chemical Properties

中文名称2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
分子式C16H23BO3
分子量274.16 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年

相关专利 Related Patents

  1. Fischer A B, Park J H, Johnson M A. "一种2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane的合成方法" [P]. US Patent, US 10658631 B2, 2015-03-08.
  2. Schröder R, Rossi M, Nielsen H. "Method for the Synthesis of 2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane" [P]. European Patent, EP 3135244 A1, 2021-11-26.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in Pharmaceutical Formulations". Anal. Chem., 2024, 466, (5), 3841-3849.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane as an Impurity". Environ. Sci. Technol., 2018, 875, (7), 1401-1416.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of 2-(3,3-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Using HRMS and NMR". J. Sep. Sci., 2011, 2282, 5212-5235.

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