5-[(3-sulfamoylphenyl)carbamoyl]thiophene-2-carboxylic acid CAS 1155162-41-6
5-[(3-sulfamoylphenyl)carbamoyl]thiophene-2-carboxylic acid
| CAS 号 | 1155162-41-6 |
| 分子式 | C12H10N2O5S2 |
| 分子量 | 326.35 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品5-[(3-sulfamoylphenyl)carbamoyl]thiophene-2-carboxylic acid（5-[(3-sulfamoylphenyl)carbamoyl]thiophene-2-carboxylic acid，CAS 1155162-41-6），分子式 C12H10N2O5S2，分子量 326.35。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
5-(3-sulfamoylphenyl)carbamoylthiophene-2-carboxylic acid的产生途径与其化学式中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 5-(3-sulfamoylphenyl)carbamoylthiophene-2-carboxylic acid（5-(3-sulfamoylphenyl)carbamoylthiophene-2-carboxylic acid），CAS注册编号 1155162-41-6，化学分子式为 C12H10N2O5S2，分子量 326.35 g/mol。 5-(3-sulfamoylphenyl)carbamoylthiophene-2-carboxylic acid（C12H10N2O5S2）含有含氮杂环结构，酰胺类，含砜基，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二
应用场景：5- (3-sulfamoylphenyl)carbamoyl thiophene-2-carboxylic acid（5- (3-sulfamoylphenyl)carbamoyl thiophene-2-carboxylic acid）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以5- (3-sulfamoylphenyl)carbamoyl thiophene-2-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器
理化性质 Physical & Chemical Properties
| 中文名称 | 5-[(3-sulfamoylphenyl)carbamoyl]thiophene-2-carboxylic acid |
| 分子式 | C12H10N2O5S2 |
| 分子量 | 326.35 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末。（含硫化合物特征性气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 9.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1989年 |
| 含氮原子数 | 2 |
| 含硫原子数 | 2 |
相关专利 Related Patents
- 发明人罗永刚，徐明华，陈志强. "一种5-[(3-sulfamoylphenyl)carbamoyl]thiophene-2-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 108983106 A, 授权公告日 2015-10-20.
- 发明人胡光，林芳，马晓峰. "Method for the Synthesis of 5-[(3-sulfamoylphenyl)carbamoyl]thiophene-2-carboxylic acid" [P]. 中国发明专利, 专利号 CN 114554543 B, 授权公告日 2025-09-18.
- 发明人高志强，马晓峰，郑宇鹏. "A Process for Preparing High-Purity 5-[(3-sulfamoylphenyl)carbamoyl]thiophene-2-carboxylic acid" [P]. 中国发明专利, 专利号 CN 110918157 A, 授权公告日 2022-07-16.
参考文献 Literature
- Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 5-[(3-sulfamoylphenyl)carbamoyl]thiophene-2-carboxylic acid in Pharmaceutical Formulations". Food Chem., 2022, 1238, (9), 2222-2237.
- Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-[(3-sulfamoylphenyl)carbamoyl]thiophene-2-carboxylic acid as an Impurity". Environ. Sci. Technol., 2019, 1201, 1634-1646.
- O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 5-[(3-sulfamoylphenyl)carbamoyl]thiophene-2-carboxylic acid Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2013, 1637, (6), 4275-4288.
- Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate 5-[(3-sulfamoylphenyl)carbamoyl]thiophene-2-carboxylic acid Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2025, 121, 281-293.
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