Tert-Butyl 6-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate CAS 1160247-36-8

Tert-Butyl 6-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate

纯度 97%+现货药物标准品
CAS 号1160247-36-8
分子式C19H27NO2
分子量301.42 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Tert-Butyl 6-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate Tert-Butyl 6-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate CAS 1160247-36-8 结构式 Chemical Structure

产品介绍 Description

Tert-Butyl 6-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate（Tert-Butyl 6-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate）是药物分析与质量控制领域常用的药物标准品，CAS 号 1160247-36-8。分子式 C19H27NO2，分子量 301.42。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

Tert-Butyl 6-Methyl-2,3-DihydrospiroIndene-1,4'-Piperidine-1'-Carboxylate（C19H27NO2）含有甾体骨架，酰胺类，含羟基，含醚键。较高的碳氢比使其脂溶性较好，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。由于碳链较长，脂溶性良好，该化合物在Octanol-Water分配系数测试中倾向于有机相。 化学式为 C19H27NO2 的Tert-Butyl 6-Methyl-2,3-DihydrospiroIndene-1,4'-Piperidine-1'-Carboxylate（Tert-Butyl 6-Methyl-2,3-DihydrospiroIndene-1,4'-Piperidine-1'-Carboxylate），其CAS登记号是 1160247-36-8，分子量为 301.42 g/mol。 本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。

应用场景：针对化学分析用途，Tert-Butyl 6-Methyl-2,3-Dihydrospiro Indene-1,4'-Piperidine -1'-Carboxylate（Tert-Butyl 6-Methyl-2,3-Dihydrospiro Indene-1,4'-Piperidine -1'-Carboxylate）是具有明确定量溯源的认证级对照品。 推荐以Tert-Butyl 6-Methyl-2,3-Dihydrospiro Indene-1,4'-Piperidine -1'-Carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）

理化性质 Physical & Chemical Properties

中文名称Tert-Butyl 6-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
分子式C19H27NO2
分子量301.42 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
含氮原子数1

相关专利 Related Patents

  1. Schröder R, Yamamoto T, Johnson M A. "一种Tert-Butyl 6-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate的合成方法" [P]. US Patent, US 9332347 B2, 2022-03-06.
  2. Brown S R, Fischer A B, Hughes D C. "Method for the Synthesis of Tert-Butyl 6-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate" [P]. US Patent, US 9627589 B2, 2017-11-18.
  3. 发明人沈红梅，孙丽萍，林芳. "A Process for Preparing High-Purity Tert-Butyl 6-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate" [P]. 中国发明专利, 专利号 CN 114611195 B, 授权公告日 2016-02-23.

参考文献 Literature

  1. Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of Tert-Butyl 6-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate in Pharmaceutical Formulations". Molecules, 2020, 1899, 6740-6749.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of Tert-Butyl 6-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate as an Impurity". Anal. Chem., 2013, 1620, 7078-7105.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of Tert-Butyl 6-Methyl-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate Using HRMS and NMR". Anal. Chim. Acta, 2025, 1520, (4), 5205-5231.

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