2-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)ethanamine hydrochloride CAS 1170562-90-9

2-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)ethanamine hydrochloride

纯度 97%+现货药物标准品
CAS 号1170562-90-9
分子式C9H18N2O4S HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)ethanamine hydrochloride 2-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)ethanamine hydrochloride CAS 1170562-90-9 结构式 Chemical Structure

产品介绍 Description

2-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)ethanamine hydrochloride（2-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)ethanamine hydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 1170562-90-9。分子式 C9H18N2O4S HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

2-(1,4-dioxa-8-azaspiro4.5dec-8-ylsulfonyl)ethanamine hydrochloride的产生途径与其化学式中酰胺类，含砜基，羧酸类，含羟基，含醚键，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C9H18N2O4S HCl 的2-(1,4-dioxa-8-azaspiro4.5dec-8-ylsulfonyl)ethanamine hydrochloride（2-(1,4-dioxa-8-azaspiro4.5dec-8-ylsulfonyl)ethanamine hydrochloride），其CAS登记号是 1170562-90-9，分子量为 286.77 g/mol。 受分子结构中酰胺类，含砜基，羧酸类，含羟基，含醚键，含氯取代的影响，2-(1,4-dioxa-8-azaspiro4.5dec-8-ylsulfonyl)ethanamine hydrochloride表现为白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，含硫化合物特征性气味）。其

应用场景：2-(1,4-dioxa-8-azaspiro 4.5 dec-8-ylsulfonyl)ethanamine hydrochloride（2-(1,4-dioxa-8-azaspiro 4.5 dec-8-ylsulfonyl)ethanamine hydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以2-(1,4-dioxa-8-azaspiro 4.5 dec-8-ylsulfonyl)ethanamine hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。

理化性质 Physical & Chemical Properties

中文名称2-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)ethanamine hydrochloride
分子式C9H18N2O4S HCl
分子量286.77 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1989年
卤素含量Cl取代
含氮原子数2
含硫原子数1

相关专利 Related Patents

  1. Chen K W, Klinger H, Fischer A B. "一种2-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)ethanamine hydrochloride的合成方法" [P]. US Patent, US 11266776 B2, 2023-01-01.
  2. Roberts E F, Kumar R, Klinger H. "Method for the Synthesis of 2-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)ethanamine hydrochloride" [P]. US Patent, US 11501164 B2, 2025-05-20.
  3. Kumar R, Roberts E F, Patel M V. "A Process for Preparing High-Purity 2-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)ethanamine hydrochloride" [P]. US Patent, US 11564533 B2, 2021-06-14.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)ethanamine hydrochloride in Pharmaceutical Formulations". Molecules, 2017, 803, (4), 879-894.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)ethanamine hydrochloride as an Impurity". Sci. Total Environ., 2019, 1991, (2), 1954-1973.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 2-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylsulfonyl)ethanamine hydrochloride Using HRMS and NMR". Biomed. Chromatogr., 2020, 1200, 2667-2679.

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