3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo[5,4-b]pyridine-4-carboxylic acid CAS 1171943-74-0

3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo[5,4-b]pyridine-4-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1171943-74-0
分子式C14H14N4O3
分子量286.29 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo[5,4-b]pyridine-4-carboxylic acid 3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo[5,4-b]pyridine-4-carboxylic acid CAS 1171943-74-0 结构式 Chemical Structure

产品介绍 Description

3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo[5,4-b]pyridine-4-carboxylic acid（3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo[5,4-b]pyridine-4-carboxylic acid）是药物分析与质量控制领域常用的药物标准品，CAS 号 1171943-74-0。分子式 C14H14N4O3，分子量 286.29。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo5,4-bpyridine-4-carboxylic acid（3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo5,4-bpyridine-4-carboxylic acid），CAS注册编号 1171943-74-0，化学分子式为 C14H14N4O3，分子量 286.29 g/mol。 3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo5,4-bpyridine-4-carboxylic acid（C14H14N4O3）含有含氮杂环结构，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。由于结构中存在共轭发色团

应用场景：3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo 5,4-b pyridine-4-carboxylic acid（3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo 5,4-b pyridine-4-carboxylic acid，CAS 1171943-74-0）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo 5,4-b pyridine-4-carbox

理化性质 Physical & Chemical Properties

中文名称3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo[5,4-b]pyridine-4-carboxylic acid
分子式C14H14N4O3
分子量286.29 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
含氮原子数4

相关专利 Related Patents

  1. 发明人刘建华，钱学锋，黄志刚. "一种3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo[5,4-b]pyridine-4-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 112952108 B, 授权公告日 2024-05-15.
  2. 发明人黄志刚，赵玉洁，高志强. "Method for the Synthesis of 3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo[5,4-b]pyridine-4-carboxylic acid" [P]. 中国发明专利, 专利号 CN 114984848 A, 授权公告日 2018-12-05.
  3. Schröder R, Mueller T C, Sørensen M. "A Process for Preparing High-Purity 3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo[5,4-b]pyridine-4-carboxylic acid" [P]. European Patent, EP 3178282 A1, 2016-01-08.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of 3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo[5,4-b]pyridine-4-carboxylic acid in Pharmaceutical Formulations". Anal. Chem., 2017, 1028, (9), 1563-1591.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo[5,4-b]pyridine-4-carboxylic acid as an Impurity". Chemosphere, 2022, 692, (5), 9900-9929.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-6-methylisoxazolo[5,4-b]pyridine-4-carboxylic acid Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2017, 1409, 307-336.

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