5-[(3-methylpiperidin-1-yl)methyl]thiophene-2-carboxylic acid CAS 1174887-28-5

5-[(3-methylpiperidin-1-yl)methyl]thiophene-2-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1174887-28-5
分子式C12H17NO2S
分子量239.33 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-[(3-methylpiperidin-1-yl)methyl]thiophene-2-carboxylic acid 5-[(3-methylpiperidin-1-yl)methyl]thiophene-2-carboxylic acid CAS 1174887-28-5 结构式 Chemical Structure

产品介绍 Description

5-[(3-methylpiperidin-1-yl)methyl]thiophene-2-carboxylic acid（5-[(3-methylpiperidin-1-yl)methyl]thiophene-2-carboxylic acid）是药物分析与质量控制领域常用的药物标准品，CAS 号 1174887-28-5。分子式 C12H17NO2S，分子量 239.33。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，5-(3-methylpiperidin-1-yl)methylthiophene-2-carboxylic acid的分子量为239.33 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 5-(3-methylpiperidin-1-yl)methylthiophene-2-carboxylic acid（5-(3-methylpiperidin-1-yl)methylthiophene-2-carboxylic acid），CAS注册编号 1174887-28-5，化学分子式为 C12H17NO2S，分子量 239.33 g/mol。 从化学结构特征来看，5-(3-methylpiperidin-1-yl)methylthiophene-2-carboxylic acid的分子骨架中包含含氮杂环结构，酰胺类，含砜基，含羟基，含醚键。该化合物的不饱和度为5.0，表明结构中存在约5个环或双键等价单元。分子量为239.33 g/mol，属于中等分子量化合物。较高的碳氢原子比赋予该化合物良好的脂溶性，可使用正己烷或乙酸乙酯等非

应用场景：在化学分析实验室中，5- (3-methylpiperidin-1-yl)methyl thiophene-2-carboxylic acid（CAS 1174887-28-5）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以5- (3-methylpiperidin-1-yl)methyl thiophene-2-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇

理化性质 Physical & Chemical Properties

中文名称5-[(3-methylpiperidin-1-yl)methyl]thiophene-2-carboxylic acid
分子式C12H17NO2S
分子量239.33 g/mol
外观形态类白色至淡黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
含氮原子数1
含硫原子数1

相关专利 Related Patents

  1. Nielsen H, Kowalski A, Johansson L. "一种5-[(3-methylpiperidin-1-yl)methyl]thiophene-2-carboxylic acid的合成方法" [P]. European Patent, EP 3271609 A1, 2023-02-02.
  2. Johansson L, Jørgensen K, Rossi M. "Method for the Synthesis of 5-[(3-methylpiperidin-1-yl)methyl]thiophene-2-carboxylic acid" [P]. European Patent, EP 3892746 A1, 2019-06-05.
  3. Lee S K, Brown S R, Hughes D C. "A Process for Preparing High-Purity 5-[(3-methylpiperidin-1-yl)methyl]thiophene-2-carboxylic acid" [P]. US Patent, US 11558939 B2, 2020-04-12.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 5-[(3-methylpiperidin-1-yl)methyl]thiophene-2-carboxylic acid in Pharmaceutical Formulations". Anal. Chim. Acta, 2010, 960, (11), 8016-8027.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-[(3-methylpiperidin-1-yl)methyl]thiophene-2-carboxylic acid as an Impurity". Food Chem., 2019, 1521, (1), 1117-1141.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 5-[(3-methylpiperidin-1-yl)methyl]thiophene-2-carboxylic acid Using HRMS and NMR". J. Nat. Prod., 2023, 1757, 4369-4376.
  4. Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate 5-[(3-methylpiperidin-1-yl)methyl]thiophene-2-carboxylic acid Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2023, 1197, 7231-7236.

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