(S)-N-[3-(6-异丙氧基-3-吡啶基)-5-吲唑基]-1-[2-[4-[4-(1-甲基-1H-1,2,4-三唑-3-基)苯基]-5,6-二氢吡啶-1(2H)-基]-2-氧代乙基]-3-(甲硫基)吡咯烷-3-甲酰胺 CAS 1184173-73-6

(S)-N-[3-(6-Isopropoxy-3-pyridyl)-5-indazolyl]-1-[2-[4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-5,6-dihydropyridin-1(2H)-yl]-2-oxoethyl]-3-(methylthio)pyrrolidine-3-carboxamide

纯度 97%+现货药物标准品
CAS 号1184173-73-6
分子式C37H41N9O3S
分子量691.84 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(S)-N-[3-(6-异丙氧基-3-吡啶基)-5-吲唑基]-1-[2-[4-[4-(1-甲基-1H-1,2,4-三唑-3-基)苯基]-5,6-二氢吡啶-1(2H)-基]-2-氧代乙基]-3-(甲硫基)吡咯烷-3-甲酰胺 (S)-N-[3-(6-Isopropoxy-3-pyridyl)-5-indazolyl]-1-[2-[4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-5,6-dihydropyridin-1(2H)-yl]-2-oxoethyl]-3-(methylthio)pyrrolidine-3-carboxamide CAS 1184173-73-6 结构式 Chemical Structure

产品介绍 Description

(S)-N-[3-(6-异丙氧基-3-吡啶基)-5-吲唑基]-1-[2-[4-[4-(1-甲基-1H-1,2,4-三唑-3-基)苯基]-5,6-二氢吡啶-1(2H)-基]-2-氧代乙基]-3-(甲硫基)吡咯烷-3-甲酰胺（(S)-N-[3-(6-Isopropoxy-3-pyridyl)-5-indazolyl]-1-[2-[4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-5,6-dihydropyridin-1(2H)-yl]-2-oxoethyl]-3-(methylthio)pyrrolidine-3-carboxamide，CAS 号 1184173-73-6）是 CATO 佳途自主生产的药物标准品，分子式 C37H41N9O3S，分子量 691.84。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，(S)-N-3-(6-异丙氧基-3-吡啶基)-5-吲唑基-1-2-4-4-(1-甲基-1H-1,2,4-三唑-3-基)苯基-5,6-二氢吡啶-1(2H)-基-2-氧代乙基-3-(甲硫基)吡咯烷-3-甲酰胺的分子量为691.84 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C37H41N9O3S 的(S)-N-3-(6-异丙氧基-3-吡啶基)-5-吲唑基-1-2-4-4-(1-甲基-1H-1,2,4-三唑-3-基)苯基-5,6-二氢吡啶-1(2H)-基-2-氧代乙基-3-(甲硫基)吡咯烷-3-甲酰胺（(S)-N-3-(6-Isopropoxy-3-pyridyl)-5-indazolyl-1-2-4-4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl-5,6-dihydropyridin-1(2H)-yl-2-oxoethyl-3-(methylthio)pyrrolidine-3-carboxamide），其CAS登记号是 1184173-73-6，

应用场景：针对化学分析用途，(S)-N- 3-(6-异丙氧基-3-吡啶基)-5-吲唑基 -1- 2- 4- 4-(1-甲基-1H-1,2,4-三唑-3-基)苯基 -5,6-二氢吡啶-1(2H)-基 -2-氧代乙基 -3-(甲硫基)吡咯烷-3-甲酰胺（(S)-N- 3-(6-Isopropoxy-3-pyridyl)-5-indazolyl -1- 2- 4- 4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl -5,6-dihydropyridin-1(2H)-yl -2-oxoethyl -3-(methylthio)pyrrolidine-3-carboxamide）是

理化性质 Physical & Chemical Properties

中文名称(S)-N-[3-(6-异丙氧基-3-吡啶基)-5-吲唑基]-1-[2-[4-[4-(1-甲基-1H-1,2,4-三唑-3-基)苯基]-5,6-二氢吡啶-1(2H)-基]-2-氧代乙基]-3-(甲硫基)吡咯烷-3-甲酰胺
分子式C37H41N9O3S
分子量691.84 g/mol
外观形态淡黄色至黄色无定形粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）22.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
含氮原子数9
含硫原子数1

相关专利 Related Patents

  1. 发明人陈志强，马晓峰，高志强. "一种(S)-N-[3-(6-异丙氧基-3-吡啶基)-5-吲唑基]-1-[2-[4-[4-(1-甲基-1H-1,2,4-三唑-3-基)苯基]-5,6-二氢吡啶-1(2H)-基]-2-氧代乙基]-3-(甲硫基)吡咯烷-3-甲酰胺的合成方法" [P]. 中国发明专利, 专利号 CN 113899890 A, 授权公告日 2017-07-04.
  2. 发明人罗永刚，孙丽萍，何建平. "Method for the Synthesis of (S)-N-[3-(6-Isopropoxy-3-pyridyl)-5-indazolyl]-1-[2-[4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-5,6-dihydropyridin-1(2H)-yl]-2-oxoethyl]-3-(methylthio)pyrrolidine-3-carboxamide" [P]. 中国发明专利, 专利号 CN 116307727 A, 授权公告日 2018-09-01.
  3. Roberts E F, Fischer A B, Kumar R. "A Process for Preparing High-Purity (S)-N-[3-(6-Isopropoxy-3-pyridyl)-5-indazolyl]-1-[2-[4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-5,6-dihydropyridin-1(2H)-yl]-2-oxoethyl]-3-(methylthio)pyrrolidine-3-carboxamide" [P]. US Patent, US 9748772 B2, 2025-05-06.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of (S)-N-[3-(6-异丙氧基-3-吡啶基)-5-吲唑基]-1-[2-[4-[4-(1-甲基-1H-1,2,4-三唑-3-基)苯基]-5,6-二氢吡啶-1(2H)-基]-2-氧代乙基]-3-(甲硫基)吡咯烷-3-甲酰胺 in Pharmaceutical Formulations". J. Chromatogr. A, 2016, 134, (9), 8760-8764.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of (S)-N-[3-(6-异丙氧基-3-吡啶基)-5-吲唑基]-1-[2-[4-[4-(1-甲基-1H-1,2,4-三唑-3-基)苯基]-5,6-二氢吡啶-1(2H)-基]-2-氧代乙基]-3-(甲硫基)吡咯烷-3-甲酰胺 as an Impurity". Anal. Methods, 2022, 1047, (2), 9346-9358.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of (S)-N-[3-(6-Isopropoxy-3-pyridyl)-5-indazolyl]-1-[2-[4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-5,6-dihydropyridin-1(2H)-yl]-2-oxoethyl]-3-(methylthio)pyrrolidine-3-carboxamide Using HRMS and NMR". Food Chem., 2018, 2079, (12), 5930-5949.

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