1-(piperidin-4-yl)-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione hydrochloride CAS 1193388-38-3

1-(piperidin-4-yl)-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione hydrochloride

纯度 97%+现货药物标准品
CAS 号1193388-38-3
分子式C9H12N6O2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-(piperidin-4-yl)-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione hydrochloride 1-(piperidin-4-yl)-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione hydrochloride CAS 1193388-38-3 结构式 Chemical Structure

产品介绍 Description

1-(piperidin-4-yl)-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione hydrochloride（1-(piperidin-4-yl)-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione hydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 1193388-38-3。分子式 C9H12N6O2 HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括1-(piperidin-4-yl)-1H,4H,5H,6H,7H-1,2,3triazolo4,5-dpyridazine-4,7-dione hydrochloride在内的目标物的控制。 化学式为 C9H12N6O2 HCl 的1-(piperidin-4-yl)-1H,4H,5H,6H,7H-1,2,3triazolo4,5-dpyridazine-4,7-dione hydrochloride（1-(piperidin-4-yl)-1H,4H,5H,6H,7H-1,2,3triazolo4,5-dpyridazine-4,7-dione hydrochloride），其CAS登记号是 1193388-38-3，分子量为 272.69 g/mol。 依据分子式为 C9H12N6O2 HCl 的1-(piperidin-4-yl)-1H,4H,5H,6H,7H-1,2,3triazolo4,5-dpyridazine-4,7-dione hydrochloride结构特征，其分子内含含

应用场景：从实际应用出发，1-(piperidin-4-yl)-1H,4H,5H,6H,7H- 1,2,3 triazolo 4,5-d pyridazine-4,7-dione hydrochloride（CAS 1193388-38-3）在化学分析中作为关键的基准对照物质。 推荐以1-(piperidin-4-yl)-1H,4H,5H,6H,7H- 1,2,3 triazolo 4,5-d pyridazine-4,7-dione hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使

理化性质 Physical & Chemical Properties

中文名称1-(piperidin-4-yl)-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione hydrochloride
分子式C9H12N6O2 HCl
分子量272.69 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
卤素含量Cl取代
含氮原子数6

相关专利 Related Patents

  1. Schröder R, Hughes D C, Mueller T. "一种1-(piperidin-4-yl)-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione hydrochloride的合成方法" [P]. US Patent, US 11974579 B2, 2015-07-04.
  2. 发明人林芳，周伟，唐晓军. "Method for the Synthesis of 1-(piperidin-4-yl)-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione hydrochloride" [P]. 中国发明专利, 专利号 CN 108225602 B, 授权公告日 2024-01-20.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of 1-(piperidin-4-yl)-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione hydrochloride in Pharmaceutical Formulations". Talanta, 2013, 888, 674-704.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-(piperidin-4-yl)-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione hydrochloride as an Impurity". J. Nat. Prod., 2020, 489, 8666-8683.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 1-(piperidin-4-yl)-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione hydrochloride Using HRMS and NMR". Chromatographia, 2023, 2123, (11), 1997-2015.

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