tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate CAS 1198103-89-7

tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

纯度 97%+现货药物标准品
CAS 号1198103-89-7
分子式C18H32N2O2Si
分子量336.54 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate CAS 1198103-89-7 结构式 Chemical Structure

产品介绍 Description

tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate（tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate）是药物分析与质量控制领域常用的药物标准品，CAS 号 1198103-89-7。分子式 C18H32N2O2Si，分子量 336.54。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo2,3-bpyridine-1-carboxylate的产生途径与其化学式中甾体骨架，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C18H32N2O2Si 的tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo2,3-bpyridine-1-carboxylate（tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo2,3-bpyridine-1-carboxylate），其CAS登记号是 1198103-89-7，分子量为 336.54 g/mol。 依据分子式为 C18H32N2O2Si 的tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo2,3-bpyridine-1-carboxylate结构特

应用场景：tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo 2,3-b pyridine-1-carboxylate（tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo 2,3-b pyridine-1-carboxylate）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo 2,3-b pyridine-1-carboxylate配制标准系列

理化性质 Physical & Chemical Properties

中文名称tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
分子式C18H32N2O2Si
分子量336.54 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
含氮原子数2

相关专利 Related Patents

  1. Lee S K, Kumar R, Stevens L M. "一种tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate的合成方法" [P]. US Patent, US 9121142 B2, 2016-08-03.
  2. Hughes D C, Schröder R, Davis P L. "Method for the Synthesis of tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate" [P]. US Patent, US 11703622 B2, 2019-08-23.
  3. 发明人陈志强，胡光，周伟. "A Process for Preparing High-Purity tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate" [P]. 中国发明专利, 专利号 CN 110344633 B, 授权公告日 2020-08-01.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate in Pharmaceutical Formulations". J. Nat. Prod., 2013, 1130, (2), 680-688.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate as an Impurity". Food Chem., 2017, 581, 6063-6071.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate Using HRMS and NMR". Molecules, 2010, 2358, 4912-4926.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate tert-Butyl 5-methyl-3-((trimethylsilyl)ethynyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2022, 1245, (5), 8751-8776.

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