1-methyl-4-[2-(1-methylpiperidin-4-yl)ethyl]piperazine CAS 1208678-08-3

1-methyl-4-[2-(1-methylpiperidin-4-yl)ethyl]piperazine

纯度 97%+现货药物标准品
CAS 号1208678-08-3
分子式C13H27N3
分子量225.37 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-methyl-4-[2-(1-methylpiperidin-4-yl)ethyl]piperazine 1-methyl-4-[2-(1-methylpiperidin-4-yl)ethyl]piperazine CAS 1208678-08-3 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的1-methyl-4-[2-(1-methylpiperidin-4-yl)ethyl]piperazine（1-methyl-4-[2-(1-methylpiperidin-4-yl)ethyl]piperazine）为药物标准品，CAS 登记号 1208678-08-3，分子式 C13H27N3，分子量 225.37。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

与同类药物标准品相比，1-methyl-4-2-(1-methylpiperidin-4-yl)ethylpiperazine的分子量为225.37 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 1-methyl-4-2-(1-methylpiperidin-4-yl)ethylpiperazine（1-methyl-4-2-(1-methylpiperidin-4-yl)ethylpiperazine），CAS注册编号 1208678-08-3，化学分子式为 C13H27N3，分子量 225.37 g/mol。 从化学结构特征来看，1-methyl-4-2-(1-methylpiperidin-4-yl)ethylpiperazine的分子骨架中包含含氰基。该化合物的不饱和度为2.0，表明结构中存在约2个环或双键等价单元。分子量为225.37 g/mol，属于中等分子量化合物。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析

应用场景：1-methyl-4- 2-(1-methylpiperidin-4-yl)ethyl piperazine（1-methyl-4- 2-(1-methylpiperidin-4-yl)ethyl piperazine，CAS 1208678-08-3）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以1-methyl-4- 2-(1-methylpiperidin-4-yl)ethyl piperazine配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约

理化性质 Physical & Chemical Properties

中文名称1-methyl-4-[2-(1-methylpiperidin-4-yl)ethyl]piperazine
分子式C13H27N3
分子量225.37 g/mol
外观形态白色至类白色低熔点固体
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1990年
含氮原子数3

相关专利 Related Patents

  1. Thompson G K, Stevens L M, Johnson M A. "一种1-methyl-4-[2-(1-methylpiperidin-4-yl)ethyl]piperazine的合成方法" [P]. US Patent, US 11590510 B2, 2018-08-22.
  2. Jørgensen K, Mueller T C, Sørensen M. "Method for the Synthesis of 1-methyl-4-[2-(1-methylpiperidin-4-yl)ethyl]piperazine" [P]. European Patent, EP 3985713 A1, 2025-09-23.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of 1-methyl-4-[2-(1-methylpiperidin-4-yl)ethyl]piperazine in Pharmaceutical Formulations". Chromatographia, 2016, 1776, (5), 6017-6036.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-methyl-4-[2-(1-methylpiperidin-4-yl)ethyl]piperazine as an Impurity". Phytochemistry, 2024, 2459, (8), 4879-4888.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 1-methyl-4-[2-(1-methylpiperidin-4-yl)ethyl]piperazine Using HRMS and NMR". J. Agric. Food Chem., 2014, 1517, (12), 7484-7492.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate 1-methyl-4-[2-(1-methylpiperidin-4-yl)ethyl]piperazine Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2019, 729, (2), 8541-8550.

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