5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride CAS 1209773-69-2

5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride

纯度 97%+现货药物标准品
CAS 号1209773-69-2
分子式C13H12N2O2S HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride 5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride CAS 1209773-69-2 结构式 Chemical Structure

产品介绍 Description

CAS 1209773-69-2 对应的5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride（5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C13H12N2O2S HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride在内的目标物的控制。 5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride（5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride），CAS注册编号 1209773-69-2，化学分子式为 C13H12N2O2S HCl，分子量 296.77 g/mol。 受分子结构中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键，含氯取代的影响，5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride表现为淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味）。其固体形态的物理化学属性——包

应用场景：针对化学分析用途，5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride（5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride）是具有明确定量溯源的认证级对照品。 推荐以5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）

理化性质 Physical & Chemical Properties

中文名称5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride
分子式C13H12N2O2S HCl
分子量296.77 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年
卤素含量Cl取代
含氮原子数2
含硫原子数1

相关专利 Related Patents

  1. 发明人唐晓军，冯建国，郭海燕. "一种5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 108890630 B, 授权公告日 2024-03-26.
  2. 发明人杨光，钱学锋，何建平. "Method for the Synthesis of 5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride" [P]. 中国发明专利, 专利号 CN 115863529 A, 授权公告日 2018-01-23.
  3. 发明人钱学锋，刘建华，杨光. "A Process for Preparing High-Purity 5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride" [P]. 中国发明专利, 专利号 CN 110578724 B, 授权公告日 2022-07-18.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of 5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride in Pharmaceutical Formulations". J. Chromatogr. A, 2025, 1813, (7), 5352-5369.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride as an Impurity". Talanta, 2025, 2376, (3), 2402-2416.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride Using HRMS and NMR". J. Pharm. Biomed. Anal., 2021, 198, (1), 6266-6276.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate 5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2018, 1437, 8214-8224.

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