2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride CAS 1221725-69-4

2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride

纯度 97%+现货药物标准品
CAS 号1221725-69-4
分子式C16H17F3N2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride CAS 1221725-69-4 结构式 Chemical Structure

产品介绍 Description

2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride（2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 1221725-69-4。分子式 C16H17F3N2 HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

2-methyl-1-3-(trifluoromethyl)phenyl-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride的产生途径与其化学式中含氮杂环结构，含氰基，含氟/氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C16H17F3N2 HCl 的2-methyl-1-3-(trifluoromethyl)phenyl-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride（2-methyl-1-3-(trifluoromethyl)phenyl-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride），其CAS登记号是 1221725-69-4，分子量为 330.78 g/mol。 2-methyl-1-3-(trifluoromethyl)phenyl-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride（C16H17F3N2 HCl）含

应用场景：2-methyl-1- 3-(trifluoromethyl)phenyl -4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride（2-methyl-1- 3-(trifluoromethyl)phenyl -4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以2-methyl-1- 3-(trifluoromethyl)phenyl -4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride配制标

理化性质 Physical & Chemical Properties

中文名称2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride
分子式C16H17F3N2 HCl
分子量330.78 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年
卤素含量F/Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人周伟，何建平，郑宇鹏. "一种2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 110649444 A, 授权公告日 2024-12-10.
  2. 发明人赵玉洁，李文辉，郭海燕. "Method for the Synthesis of 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride" [P]. 中国发明专利, 专利号 CN 115639578 A, 授权公告日 2016-01-09.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2023, 1162, (7), 5208-5230.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride as an Impurity". Anal. Chem., 2013, 2000, 2194-2201.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride Using HRMS and NMR". Chromatographia, 2018, 449, 9817-9827.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 2-methyl-1-[3-(trifluoromethyl)phenyl]-4,5,6,7-tetrahydro-1H-indol-4-amine hydrochloride Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2024, 522, (10), 7726-7732.

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