1,2,3,4,6-戊-O-(3,4,5-三-O-苄基没食子酰)-beta-D-吡喃葡萄糖 CAS 122625-60-9

(2S,3R,4S,5R,6R)-6-(((3,4,5-Tris(benzyloxy)benzoyl)oxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(3,4,5-tris(benzyloxy)benzoate)

纯度 97%+现货药物标准品
CAS 号122625-60-9
分子式C146H122O26
分子量2292.52 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1,2,3,4,6-戊-O-(3,4,5-三-O-苄基没食子酰)-beta-D-吡喃葡萄糖 (2S,3R,4S,5R,6R)-6-(((3,4,5-Tris(benzyloxy)benzoyl)oxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(3,4,5-tris(benzyloxy)benzoate) CAS 122625-60-9 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品1,2,3,4,6-戊-O-(3,4,5-三-O-苄基没食子酰)-beta-D-吡喃葡萄糖（(2S,3R,4S,5R,6R)-6-(((3,4,5-Tris(benzyloxy)benzoyl)oxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(3,4,5-tris(benzyloxy)benzoate)，CAS 122625-60-9），分子式 C146H122O26，分子量 2292.52。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

作为认证标准物质（CRM），1,2,3,4,6-戊-O-(3,4,5-三-O-苄基没食子酰)-beta-D-吡喃葡萄糖满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 CAS编号 122625-60-9 对应的化合物1,2,3,4,6-戊-O-(3,4,5-三-O-苄基没食子酰)-beta-D-吡喃葡萄糖（英文标识 (2S,3R,4S,5R,6R)-6-(((3,4,5-Tris(benzyloxy)benzoyl)oxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(3,4,5-tris(benzyloxy)benzoate)），化学式 C146H122O26，相对分子质量 2292.52。 1,2,3,4,6-戊-O-(3,4,5-三-O-苄基没食子酰)-beta-D-吡喃葡萄糖（分子式 C146H122O26）的化学结构中包含羧酸类，含羟基，含醚键，多环芳烃。在反相色谱体系中，其保

应用场景：针对化学分析用途，1,2,3,4,6-戊-O-(3,4,5-三-O-苄基没食子酰)-beta-D-吡喃葡萄糖（(2S,3R,4S,5R,6R)-6-(((3,4,5-Tris(benzyloxy)benzoyl)oxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(3,4,5-tris(benzyloxy)benzoate)）是具有明确定量溯源的认证级对照品。 推荐以1,2,3,4,6-戊-O-(3,4,5-三-O-苄基没食子酰)-beta-D-吡喃葡萄糖配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储

理化性质 Physical & Chemical Properties

中文名称1,2,3,4,6-戊-O-(3,4,5-三-O-苄基没食子酰)-beta-D-吡喃葡萄糖
分子式C146H122O26
分子量2292.52 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）86.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1992年

相关专利 Related Patents

  1. Rossi M, Björnsson E, Schröder R. "一种1,2,3,4,6-戊-O-(3,4,5-三-O-苄基没食子酰)-beta-D-吡喃葡萄糖的合成方法" [P]. European Patent, EP 3202463 A1, 2019-02-03.
  2. Anderson J P, Brown S R, Hughes D C. "Method for the Synthesis of (2S,3R,4S,5R,6R)-6-(((3,4,5-Tris(benzyloxy)benzoyl)oxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(3,4,5-tris(benzyloxy)benzoate)" [P]. US Patent, US 10101387 B2, 2024-01-03.
  3. 发明人刘建华，朱建伟，罗永刚. "A Process for Preparing High-Purity (2S,3R,4S,5R,6R)-6-(((3,4,5-Tris(benzyloxy)benzoyl)oxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(3,4,5-tris(benzyloxy)benzoate)" [P]. 中国发明专利, 专利号 CN 116622880 B, 授权公告日 2019-02-28.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 1,2,3,4,6-戊-O-(3,4,5-三-O-苄基没食子酰)-beta-D-吡喃葡萄糖 in Pharmaceutical Formulations". J. Sep. Sci., 2014, 962, 2342-2357.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1,2,3,4,6-戊-O-(3,4,5-三-O-苄基没食子酰)-beta-D-吡喃葡萄糖 as an Impurity". Rapid Commun. Mass Spectrom., 2011, 818, (6), 5704-5724.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of (2S,3R,4S,5R,6R)-6-(((3,4,5-Tris(benzyloxy)benzoyl)oxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(3,4,5-tris(benzyloxy)benzoate) Using HRMS and NMR". J. Agric. Food Chem., 2023, 504, (1), 101-131.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate 1,2,3,4,6-戊-O-(3,4,5-三-O-苄基没食子酰)-beta-D-吡喃葡萄糖 Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2014, 1898, (10), 8503-8517.

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