5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one CAS 1235438-83-1

5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one

纯度 97%+现货药物标准品
CAS 号1235438-83-1
分子式C11H11N3O2S
分子量249.29 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one 5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one CAS 1235438-83-1 结构式 Chemical Structure

产品介绍 Description

5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one（5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one，CAS 号 1235438-83-1）是 CATO 佳途自主生产的药物标准品，分子式 C11H11N3O2S，分子量 249.29。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one的产生途径与其化学式中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C11H11N3O2S 的5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one（5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one），其CAS登记号是 1235438-83-1，分子量为 249.29 g/mol。 5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one（C11H11N3O2S）含有含氮杂环结构，酰胺类，含砜基，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的

应用场景：5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one（5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one，CAS 1235438-83-1）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙

理化性质 Physical & Chemical Properties

中文名称5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one
分子式C11H11N3O2S
分子量249.29 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年
含氮原子数3
含硫原子数1

相关专利 Related Patents

  1. 发明人李文辉，朱建伟，陈志强. "一种5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one的合成方法" [P]. 中国发明专利, 专利号 CN 114593896 B, 授权公告日 2022-03-11.
  2. 发明人沈红梅，冯建国，黄志刚. "Method for the Synthesis of 5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one" [P]. 中国发明专利, 专利号 CN 108915638 A, 授权公告日 2024-01-28.
  3. O'Brien P Q, Klinger H, Williams B T. "A Process for Preparing High-Purity 5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one" [P]. US Patent, US 10433303 B2, 2017-10-07.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one in Pharmaceutical Formulations". J. Nat. Prod., 2015, 185, 1332-1348.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-ethyl-6-hydroxy-3-(pyridin-3-yl)-2-sulfanyl-3,4-dihydropyrimidin-4-one as an Impurity". Biomed. Chromatogr., 2010, 2389, (2), 7727-7730.

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