2-methyl-6-[(piperidin-4-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride CAS 1241340-57-7

2-methyl-6-[(piperidin-4-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride

纯度 97%+现货药物标准品
CAS 号1241340-57-7
分子式C15H18N2O3 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-methyl-6-[(piperidin-4-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride 2-methyl-6-[(piperidin-4-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride CAS 1241340-57-7 结构式 Chemical Structure

产品介绍 Description

2-methyl-6-[(piperidin-4-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride（2-methyl-6-[(piperidin-4-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 1241340-57-7。分子式 C15H18N2O3 HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在质量保证方面，2-methyl-6-(piperidin-4-yl)carbonyl-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 化学式为 C15H18N2O3 HCl 的2-methyl-6-(piperidin-4-yl)carbonyl-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride（2-methyl-6-(piperidin-4-yl)carbonyl-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride），其CAS登记号是 1241340-57-7，分子量为 310.78 g/mol。 从化学结构特征来看，2-methyl-6-(piperi

应用场景：针对化学分析用途，2-methyl-6- (piperidin-4-yl)carbonyl -3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride（2-methyl-6- (piperidin-4-yl)carbonyl -3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride）是具有明确定量溯源的认证级对照品。 推荐以2-methyl-6- (piperidin-4-yl)carbonyl -3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride配制标准系列

理化性质 Physical & Chemical Properties

中文名称2-methyl-6-[(piperidin-4-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride
分子式C15H18N2O3 HCl
分子量310.78 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人黄志刚，杨光，张德明. "一种2-methyl-6-[(piperidin-4-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 108862884 A, 授权公告日 2022-05-12.
  2. 发明人孙丽萍，胡光，黄志刚. "Method for the Synthesis of 2-methyl-6-[(piperidin-4-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride" [P]. 中国发明专利, 专利号 CN 111733077 B, 授权公告日 2016-05-24.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 2-methyl-6-[(piperidin-4-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride in Pharmaceutical Formulations". Chemosphere, 2016, 2427, (7), 4197-4227.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-methyl-6-[(piperidin-4-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride as an Impurity". J. Chromatogr. A, 2011, 304, (6), 6401-6422.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 2-methyl-6-[(piperidin-4-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride Using HRMS and NMR". Molecules, 2016, 2058, 7170-7200.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 2-methyl-6-[(piperidin-4-yl)carbonyl]-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2018, 1408, 5956-5973.

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