4-[3-(dimethylamino)propyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride CAS 1251923-20-2

4-[3-(dimethylamino)propyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride

纯度 97%+现货药物标准品
CAS 号1251923-20-2
分子式C8H16N4S 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-[3-(dimethylamino)propyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride 4-[3-(dimethylamino)propyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride CAS 1251923-20-2 结构式 Chemical Structure

产品介绍 Description

4-[3-(dimethylamino)propyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride（4-[3-(dimethylamino)propyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride，CAS 号 1251923-20-2）是 CATO 佳途自主生产的药物标准品，分子式 C8H16N4S 2*HCl。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 CAS编号 1251923-20-2 对应的化合物4-3-(dimethylamino)propyl-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride（英文标识 4-3-(dimethylamino)propyl-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride），化学式 C8H16N4S 2HCl，相对分子质量 236.76。 受分子结构中含氰基，含硫有机，含氯取代的影响，4-3-(dimethylamino)propyl-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride表现为白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，含硫化合物特征性气味）。其固体形态的物理化学属性——包括236.

应用场景：4- 3-(dimethylamino)propyl -3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride（4- 3-(dimethylamino)propyl -3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以4- 3-(dimethylamino)propyl -3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydroch

理化性质 Physical & Chemical Properties

中文名称4-[3-(dimethylamino)propyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride
分子式C8H16N4S 2*HCl
分子量236.76 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1990年
卤素含量Cl取代
含氮原子数4
含硫原子数1

相关专利 Related Patents

  1. 发明人韩伟，孙丽萍，赵玉洁. "一种4-[3-(dimethylamino)propyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 116447174 B, 授权公告日 2015-06-01.
  2. 发明人孙丽萍，钱学锋，胡光. "Method for the Synthesis of 4-[3-(dimethylamino)propyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride" [P]. 中国发明专利, 专利号 CN 111965228 B, 授权公告日 2017-10-28.
  3. Davis P L, Thompson G K, Schröder R. "A Process for Preparing High-Purity 4-[3-(dimethylamino)propyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride" [P]. US Patent, US 9115694 B2, 2015-04-17.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of 4-[3-(dimethylamino)propyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride in Pharmaceutical Formulations". Anal. Chem., 2017, 895, 9357-9378.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-[3-(dimethylamino)propyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride as an Impurity". Anal. Methods, 2014, 1372, (3), 2221-2249.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 4-[3-(dimethylamino)propyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride Using HRMS and NMR". J. Nat. Prod., 2022, 1944, 21-24.
  4. Wang L, Li J, Zhang H. "Forced Degradation Studies to Evaluate 4-[3-(dimethylamino)propyl]-3-methyl-4,5-dihydro-1H-1,2,4-triazole-5-thione dihydrochloride Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2019, 1687, 1628-1648.

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