2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid CAS 1270850-79-7

2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid

纯度 97%+现货药物标准品
CAS 号1270850-79-7
分子式C12H12N2O4S
分子量280.30 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid 2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid CAS 1270850-79-7 结构式 Chemical Structure

产品介绍 Description

2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid（2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid，CAS 号 1270850-79-7）是 CATO 佳途自主生产的药物标准品，分子式 C12H12N2O4S，分子量 280.30。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，2-4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-ylacetic acid的分子量为280.30 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 1270850-79-7 对应的化合物2-4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-ylacetic acid（英文标识 2-4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-ylacetic acid），化学式 C12H12N2O4S，相对分子质量 280.30。 依据分子式为 C12H12N2O4S 的2-4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-ylacetic acid结构特征，其分子内含含氮杂环结构，酰胺类，含砜基，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 28

应用场景：针对化学分析用途，2- 4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl acetic acid（2- 4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl acetic acid）是具有明确定量溯源的认证级对照品。 推荐以2- 4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl acetic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储

理化性质 Physical & Chemical Properties

中文名称2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid
分子式C12H12N2O4S
分子量280.30 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年
含氮原子数2
含硫原子数1

相关专利 Related Patents

  1. Patel M V, Williams B T, Lee S K. "一种2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid的合成方法" [P]. US Patent, US 11211996 B2, 2025-08-05.
  2. 发明人韩伟，唐晓军，沈红梅. "Method for the Synthesis of 2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid" [P]. 中国发明专利, 专利号 CN 117405023 B, 授权公告日 2017-02-05.
  3. 发明人何建平，韩伟，林芳. "A Process for Preparing High-Purity 2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid" [P]. 中国发明专利, 专利号 CN 115110442 B, 授权公告日 2016-09-04.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid in Pharmaceutical Formulations". Chromatographia, 2014, 1115, 5298-5318.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid as an Impurity". Phytochemistry, 2025, 635, (6), 2871-2876.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid Using HRMS and NMR". Anal. Chim. Acta, 2021, 2133, 8351-8362.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 2-[4-cyclopropyl-2,5-dioxo-4-(thiophen-2-yl)imidazolidin-1-yl]acetic acid Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2023, 1987, (12), 5748-5767.

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