(4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride CAS 1286273-05-9

(4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride

纯度 97%+现货药物标准品
CAS 号1286273-05-9
分子式C11H20N2O2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride (4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride CAS 1286273-05-9 结构式 Chemical Structure

产品介绍 Description

CAS 1286273-05-9 对应的(4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride（(4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C11H20N2O2 HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括(4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride在内的目标物的控制。 (4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride（(4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride），CAS注册编号 1286273-05-9，化学分子式为 C11H20N2O2 HCl，分子量 248.75 g/mol。 从化学结构特征来看，(4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride的分子骨架中包含酰胺类，羧酸类，含羟基，含醚键，含氯取代。该化合物的不饱和度为2.0，表明结构中存在约2个环或双键等价单元。分子量为248.75 g/mol，属于中等分子量化合物。由于碳链较

应用场景：在化学分析实验室中，(4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride（CAS 1286273-05-9）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以(4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至

理化性质 Physical & Chemical Properties

中文名称(4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride
分子式C11H20N2O2 HCl
分子量248.75 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1990年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. Hughes D C, Mueller T, Lee S K. "一种(4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride的合成方法" [P]. US Patent, US 9777135 B2, 2021-08-07.
  2. Nowak P, Mueller T C, Kowalski A. "Method for the Synthesis of (4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride" [P]. European Patent, EP 3944365 A1, 2017-12-26.
  3. O'Brien P Q, Schröder R, Chen K W. "A Process for Preparing High-Purity (4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride" [P]. US Patent, US 9569292 B2, 2025-08-07.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of (4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride in Pharmaceutical Formulations". Environ. Sci. Technol., 2024, 1987, (8), 5544-5559.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of (4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride as an Impurity". J. Sep. Sci., 2016, 1715, (8), 4307-4319.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of (4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride Using HRMS and NMR". Phytochemistry, 2021, 2217, (3), 192-221.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate (4-Aminopiperidin-1-yl)(tetrahydro-2H-pyran-4-yl)methanone hydrochloride Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2019, 336, 8113-8128.

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