5-ethyl-3-{octahydropyrrolo[3,4-c]pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride CAS 1311318-14-5

5-ethyl-3-{octahydropyrrolo[3,4-c]pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride

纯度 97%+现货药物标准品
CAS 号1311318-14-5
分子式C11H18N4O 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-ethyl-3-{octahydropyrrolo[3,4-c]pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride 5-ethyl-3-{octahydropyrrolo[3,4-c]pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride CAS 1311318-14-5 结构式 Chemical Structure

产品介绍 Description

5-ethyl-3-{octahydropyrrolo[3,4-c]pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride（5-ethyl-3-{octahydropyrrolo[3,4-c]pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 1311318-14-5。分子式 C11H18N4O 2*HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在质量保证方面，5-ethyl-3-{octahydropyrrolo3,4-cpyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 化学式为 C11H18N4O 2HCl 的5-ethyl-3-{octahydropyrrolo3,4-cpyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride（5-ethyl-3-{octahydropyrrolo3,4-cpyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride），其CAS登记号是 1311318-14-5，分子量为 258.75 g/mol。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代的影响，5

应用场景：针对化学分析用途，5-ethyl-3-{octahydropyrrolo 3,4-c pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride（5-ethyl-3-{octahydropyrrolo 3,4-c pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride）是具有明确定量溯源的认证级对照品。 推荐以5-ethyl-3-{octahydropyrrolo 3,4-c pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride配制标准系列工作溶液，用

理化性质 Physical & Chemical Properties

中文名称5-ethyl-3-{octahydropyrrolo[3,4-c]pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride
分子式C11H18N4O 2*HCl
分子量258.75 g/mol
外观形态类白色至淡黄色低熔点固体。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年
卤素含量Cl取代
含氮原子数4

相关专利 Related Patents

  1. 发明人冯建国，王建平，朱建伟. "一种5-ethyl-3-{octahydropyrrolo[3,4-c]pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 110202582 A, 授权公告日 2015-06-03.
  2. 发明人陈志强，徐明华，胡光. "Method for the Synthesis of 5-ethyl-3-{octahydropyrrolo[3,4-c]pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride" [P]. 中国发明专利, 专利号 CN 114652549 B, 授权公告日 2023-04-26.
  3. Williams B T, Hughes D C, Chen K W. "A Process for Preparing High-Purity 5-ethyl-3-{octahydropyrrolo[3,4-c]pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride" [P]. US Patent, US 10127471 B2, 2015-07-17.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 5-ethyl-3-{octahydropyrrolo[3,4-c]pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride in Pharmaceutical Formulations". Phytochemistry, 2011, 917, 3339-3358.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-ethyl-3-{octahydropyrrolo[3,4-c]pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride as an Impurity". Sci. Total Environ., 2014, 868, (7), 6451-6455.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 5-ethyl-3-{octahydropyrrolo[3,4-c]pyrrol-2-ylmethyl}-1,2,4-oxadiazole dihydrochloride Using HRMS and NMR". J. Nat. Prod., 2016, 124, 8653-8666.

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