3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide CAS 1313734-57-4

3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide

纯度 97%+现货药物标准品
CAS 号1313734-57-4
分子式C8[13C]2H18N2O4
分子量232.25 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide 3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide CAS 1313734-57-4 结构式 Chemical Structure

产品介绍 Description

3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide（3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide）是药物分析与质量控制领域常用的药物标准品，CAS 号 1313734-57-4。分子式 C8[13C]2H18N2O4，分子量 232.25。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 CAS编号 1313734-57-4 对应的化合物3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide（英文标识 3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide），化学式 C813C2H18N2O4，相对分子质量 232.25。 3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide（分子式 C813C2H18N2O4）的化学结构中包含氨基酸衍生物，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-U

应用场景：针对化学分析用途，3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide（3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide）是具有明确定量溯源的认证级对照品。 推荐以3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide配制标

理化性质 Physical & Chemical Properties

中文名称3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide
分子式C8[13C]2H18N2O4
分子量232.25 g/mol
外观形态白色至类白色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1990年
含氮原子数2

相关专利 Related Patents

  1. Mueller T C, Martínez F, Rossi M. "一种3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide的合成方法" [P]. European Patent, EP 3520787 A1, 2025-11-04.
  2. Rossi M, Mueller T C, Nowak P. "Method for the Synthesis of 3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide" [P]. European Patent, EP 3433255 A1, 2015-08-03.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide in Pharmaceutical Formulations". J. Sep. Sci., 2017, 1018, (9), 8548-8558.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide as an Impurity". Molecules, 2012, 607, (1), 8930-8945.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide Using HRMS and NMR". J. Chromatogr. A, 2016, 1287, (12), 7235-7251.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate 3-Hydroxy-<SC>DL</SC>-kynurenine-(butyric-1,2-<SUP>13</SUP>C<SUB>2</SUB>) dihydrobromide Profile in Drug Substances According to ICH Guidelines". Talanta, 2019, 1265, (5), 825-844.

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