(S)-tert-Butyl 3-[(dimethylcarbamoyl)amino]piperidine-1-carboxylate CAS 1338222-35-7

(S)-tert-Butyl 3-[(dimethylcarbamoyl)amino]piperidine-1-carboxylate

纯度 97%+现货药物标准品
CAS 号1338222-35-7
分子式C13H25N3O3
分子量271.36 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(S)-tert-Butyl 3-[(dimethylcarbamoyl)amino]piperidine-1-carboxylate (S)-tert-Butyl 3-[(dimethylcarbamoyl)amino]piperidine-1-carboxylate CAS 1338222-35-7 结构式 Chemical Structure

产品介绍 Description

(S)-tert-Butyl 3-[(dimethylcarbamoyl)amino]piperidine-1-carboxylate（英文名 (S)-tert-Butyl 3-[(dimethylcarbamoyl)amino]piperidine-1-carboxylate，CAS 1338222-35-7）属于药物标准品。分子式 C13H25N3O3，分子量 271.36。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

作为认证标准物质（CRM），(S)-tert-Butyl 3-(dimethylcarbamoyl)aminopiperidine-1-carboxylate满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 CAS编号 1338222-35-7 对应的化合物(S)-tert-Butyl 3-(dimethylcarbamoyl)aminopiperidine-1-carboxylate（英文标识 (S)-tert-Butyl 3-(dimethylcarbamoyl)aminopiperidine-1-carboxylate），化学式 C13H25N3O3，相对分子质量 271.36。 受分子结构中酰胺类，羧酸类，含羟基，含醚键的影响，(S)-tert-Butyl 3-(dimethylcarbamoyl)aminopiperidine-1-carboxylate表现为白色至淡黄色结晶性粉末。其固体形态的物理化学属性——包括27

应用场景：针对化学分析用途，(S)-tert-Butyl 3- (dimethylcarbamoyl)amino piperidine-1-carboxylate（(S)-tert-Butyl 3- (dimethylcarbamoyl)amino piperidine-1-carboxylate）是具有明确定量溯源的认证级对照品。 推荐以(S)-tert-Butyl 3- (dimethylcarbamoyl)amino piperidine-1-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。

理化性质 Physical & Chemical Properties

中文名称(S)-tert-Butyl 3-[(dimethylcarbamoyl)amino]piperidine-1-carboxylate
分子式C13H25N3O3
分子量271.36 g/mol
外观形态白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1991年
含氮原子数3

相关专利 Related Patents

  1. 发明人马晓峰，陈志强，朱建伟. "一种(S)-tert-Butyl 3-[(dimethylcarbamoyl)amino]piperidine-1-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 113475787 B, 授权公告日 2021-02-13.
  2. Hughes D C, Yamamoto T, Davis P L. "Method for the Synthesis of (S)-tert-Butyl 3-[(dimethylcarbamoyl)amino]piperidine-1-carboxylate" [P]. US Patent, US 10307941 B2, 2019-02-21.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of (S)-tert-Butyl 3-[(dimethylcarbamoyl)amino]piperidine-1-carboxylate in Pharmaceutical Formulations". Phytochemistry, 2020, 2154, (4), 8893-8923.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of (S)-tert-Butyl 3-[(dimethylcarbamoyl)amino]piperidine-1-carboxylate as an Impurity". J. Sep. Sci., 2024, 1929, 3979-4007.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of (S)-tert-Butyl 3-[(dimethylcarbamoyl)amino]piperidine-1-carboxylate Using HRMS and NMR". J. Chromatogr. A, 2018, 1053, 1548-1574.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate (S)-tert-Butyl 3-[(dimethylcarbamoyl)amino]piperidine-1-carboxylate Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2011, 208, 5829-5857.

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