CAS 13977-28-1

7BJ3V657VC 13977-28-1 Embramine hydrochloride 2-((p-Bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethylethylamine hydrochloride Ethylamine, 2-((p-bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethyl-, hydrochloride Ethanamine, 2-(1-(4-bromophenyl)-1-phenylethoxy)-N,N-dimethyl-, hydrochloride Bromadryl 2-(1-(4-Bromodiphenyl)ethoxy)-N,N-dimethylethylamine hydrochloride p-Bromo-alpha-methylbenzhydryl 2-dimethylaminoethyl ether hydrochloride 1-(p-Bromophenyl)-1-phenyl-1-(2-dimethylaminoethoxy)ethane hydrochloride 2-(1-(4-Bromophenyl)-1-phenylethoxy)-N,N-dimethylethanamine hydrochloride (2-(1-p-Bromophenyl-1-phenylethoxy)ethyl)dimethylethylamine hydrochloride beta-Dimethylaminoethyl p-bromo-alpha-methylbenzhydryl ether hydrochloride EINECS 237-757-3 Mebrophenhydramine hydrochloride Mebryl Embramine HCl UNII-7BJ3V657VC

纯度 97%+现货药物标准品
CAS 号13977-28-1
分子式C18H22BrNO HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

7BJ3V657VC 13977-28-1 Embramine hydrochloride 2-((p-Bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethylethylamine hydrochloride Ethylamine, 2-((p-bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethyl-, hydrochloride Ethanamine, 2-(1-(4-bromophenyl)-1-phenylethoxy)-N,N-dimethyl-, hydrochloride Bromadryl 2-(1-(4-Bromodiphenyl)ethoxy)-N,N-dimethylethylamine hydrochloride p-Bromo-alpha-methylbenzhydryl 2-dimethylaminoethyl ether hydrochloride 1-(p-Bromophenyl)-1-phenyl-1-(2-dimethylaminoethoxy)ethane hydrochloride 2-(1-(4-Bromophenyl)-1-phenylethoxy)-N,N-dimethylethanamine hydrochloride (2-(1-p-Bromophenyl-1-phenylethoxy)ethyl)dimethylethylamine hydrochloride beta-Dimethylaminoethyl p-bromo-alpha-methylbenzhydryl ether hydrochloride EINECS 237-757-3 Mebrophenhydramine hydrochloride Mebryl Embramine HCl UNII-7BJ3V657VC CAS 13977-28-1 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品（7BJ3V657VC 13977-28-1 Embramine hydrochloride 2-((p-Bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethylethylamine hydrochloride Ethylamine, 2-((p-bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethyl-, hydrochloride Ethanamine, 2-(1-(4-bromophenyl)-1-phenylethoxy)-N,N-dimethyl-, hydrochloride Bromadryl 2-(1-(4-Bromodiphenyl)ethoxy)-N,N-dimethylethylamine hydrochloride p-Bromo-alpha-methylbenzhydryl 2-dimethylaminoethyl ether hydrochloride 1-(p-Bromophenyl)-1-phenyl-1-(2-dimethylaminoethoxy)ethane hydrochloride 2-(1-(4-Bromophenyl)-1-phenylethoxy)-N,N-dimethylethanamine hydrochloride (2-(1-p-Bromophenyl-1-phenylethoxy)ethyl)dimethylethylamine hydrochloride beta-Dimethylaminoethyl p-bromo-alpha-methylbenzhydryl ether hydrochloride EINECS 237-757-3 Mebrophenhydramine hydrochloride Mebryl Embramine HCl UNII-7BJ3V657VC，CAS 13977-28-1），分子式 C18H22BrNO HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

从化学结构特征来看，的分子骨架中包含甾体骨架，酰胺类，含羟基，含醚键，含氯/溴取代。该化合物的不饱和度为7.0，表明结构中存在约7个环或双键等价单元。分子量为384.74 g/mol，属于较高分子量化合物。较高的碳氢原子比赋予该化合物良好的脂溶性，可使用正己烷或乙酸乙酯等非极性溶剂进行液-液萃取前处理。 （7BJ3V657VC 13977-28-1 Embramine hydrochloride 2-((p-Bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethylethylamine hydrochloride Ethylamine, 2-((p-bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethyl-, hydrochloride Ethanamine, 2-(1-(4-bromophenyl)-1-phenylethoxy)-N,N-dimethyl-, hydrochloride Bromadryl 2-(1-(4-Bromodiphenyl)ethoxy)-N,N-d

应用场景：从实际应用出发，（CAS 13977-28-1）在化学分析中作为关键的基准对照物质。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称
分子式C18H22BrNO HCl
分子量384.74 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1960年
卤素含量Cl/Br取代
含氮原子数1

相关专利 Related Patents

  1. 发明人朱建伟，罗永刚，李文辉. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 113182419 A, 授权公告日 2022-09-14.
  2. 发明人刘建华，钱学锋，赵玉洁. "Method for the Synthesis of 7BJ3V657VC 13977-28-1 Embramine hydrochloride 2-((p-Bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethylethylamine hydrochloride Ethylamine, 2-((p-bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethyl-, hydrochloride Ethanamine, 2-(1-(4-bromophenyl)-1-phenylethoxy)-N,N-dimethyl-, hydrochloride Bromadryl 2-(1-(4-Bromodiphenyl)ethoxy)-N,N-dimethylethylamine hydrochloride p-Bromo-alpha-methylbenzhydryl 2-dimethylaminoethyl ether hydrochloride 1-(p-Bromophenyl)-1-phenyl-1-(2-dimethylaminoethoxy)ethane hydrochloride 2-(1-(4-Bromophenyl)-1-phenylethoxy)-N,N-dimethylethanamine hydrochloride (2-(1-p-Bromophenyl-1-phenylethoxy)ethyl)dimethylethylamine hydrochloride beta-Dimethylaminoethyl p-bromo-alpha-methylbenzhydryl ether hydrochloride EINECS 237-757-3 Mebrophenhydramine hydrochloride Mebryl Embramine HCl UNII-7BJ3V657VC" [P]. 中国发明专利, 专利号 CN 109000564 B, 授权公告日 2020-05-23.
  3. 发明人冯建国，杨光，韩伟. "A Process for Preparing High-Purity 7BJ3V657VC 13977-28-1 Embramine hydrochloride 2-((p-Bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethylethylamine hydrochloride Ethylamine, 2-((p-bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethyl-, hydrochloride Ethanamine, 2-(1-(4-bromophenyl)-1-phenylethoxy)-N,N-dimethyl-, hydrochloride Bromadryl 2-(1-(4-Bromodiphenyl)ethoxy)-N,N-dimethylethylamine hydrochloride p-Bromo-alpha-methylbenzhydryl 2-dimethylaminoethyl ether hydrochloride 1-(p-Bromophenyl)-1-phenyl-1-(2-dimethylaminoethoxy)ethane hydrochloride 2-(1-(4-Bromophenyl)-1-phenylethoxy)-N,N-dimethylethanamine hydrochloride (2-(1-p-Bromophenyl-1-phenylethoxy)ethyl)dimethylethylamine hydrochloride beta-Dimethylaminoethyl p-bromo-alpha-methylbenzhydryl ether hydrochloride EINECS 237-757-3 Mebrophenhydramine hydrochloride Mebryl Embramine HCl UNII-7BJ3V657VC" [P]. 中国发明专利, 专利号 CN 115247690 B, 授权公告日 2021-02-20.

参考文献 Literature

  1. Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Anal. Chem., 2018, 1233, 1747-1773.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Molecules, 2011, 266, (5), 4158-4184.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 7BJ3V657VC 13977-28-1 Embramine hydrochloride 2-((p-Bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethylethylamine hydrochloride Ethylamine, 2-((p-bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N-dimethyl-, hydrochloride Ethanamine, 2-(1-(4-bromophenyl)-1-phenylethoxy)-N,N-dimethyl-, hydrochloride Bromadryl 2-(1-(4-Bromodiphenyl)ethoxy)-N,N-dimethylethylamine hydrochloride p-Bromo-alpha-methylbenzhydryl 2-dimethylaminoethyl ether hydrochloride 1-(p-Bromophenyl)-1-phenyl-1-(2-dimethylaminoethoxy)ethane hydrochloride 2-(1-(4-Bromophenyl)-1-phenylethoxy)-N,N-dimethylethanamine hydrochloride (2-(1-p-Bromophenyl-1-phenylethoxy)ethyl)dimethylethylamine hydrochloride beta-Dimethylaminoethyl p-bromo-alpha-methylbenzhydryl ether hydrochloride EINECS 237-757-3 Mebrophenhydramine hydrochloride Mebryl Embramine HCl UNII-7BJ3V657VC Using HRMS and NMR". Sci. Total Environ., 2018, 1734, (4), 7221-7228.

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