应用场景:(YDB1AQ7N4L 140695-21-2 T 593 Osutidine INN GenBank M36922 Methanesulfonamide, N-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)amino)((2-(((5-((methylamino)methyl)-2-furanyl)methyl)thio)ethyl)amino)methylene)-, (E)- Osutidine (+-)-N-((E)-((p,beta-Dihydroxyphenethyl)amino)((2-((5-((methylamino)methyl)furfu
理化性质 Physical & Chemical Properties
中文名称
分子式
C19H28N4O5S2
分子量
456.58 g/mol
外观形态
淡黄色至黄色结晶性粉末。(含硫化合物特征性气味)
纯度
97%+
储存条件
阴凉处(≤25°C)保存,避光,密封防潮
溶解性参考
可溶于DMSO、DMF、甲醇
稳定性
空气中长期暴露可能发生缓慢氧化;对光敏感,应避免强光直射;具有吸湿性,开封后应立即密封
化合物类型
药物标准品
子类
原料药标准品
不饱和度(DBE)
8.0
UV特征
有紫外吸收
结构特征
含芳环
CAS登记年份(估)
1997年
含氮原子数
4
含硫原子数
2
相关专利 Related Patents
Patel M V, Roberts E F, Mueller T. "一种的合成方法" [P]. US Patent, US 9813580 B2, 2017-03-28.
Klinger H, O'Brien P Q, Stevens L M. "Method for the Synthesis of YDB1AQ7N4L
140695-21-2
T 593
Osutidine [INN]
GenBank M36922
Methanesulfonamide, N-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)amino)((2-(((5-((methylamino)methyl)-2-furanyl)methyl)thio)ethyl)amino)methylene)-, (E)-
Osutidine
(+-)-N-((E)-((p,beta-Dihydroxyphenethyl)amino)((2-((5-((methylamino)methyl)furfuryl)thio)ethyl)amino)methylene)methanesulfonamide
CCRIS 8408
UNII-YDB1AQ7N4L
T-593
T593" [P]. US Patent, US 10020603 B2, 2017-01-15.
参考文献 Literature
Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Biomed. Chromatogr., 2011, 774, (7), 2026-2040.
Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Molecules, 2014, 1972, (4), 5259-5284.
Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of YDB1AQ7N4L
140695-21-2
T 593
Osutidine [INN]
GenBank M36922
Methanesulfonamide, N-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)amino)((2-(((5-((methylamino)methyl)-2-furanyl)methyl)thio)ethyl)amino)methylene)-, (E)-
Osutidine
(+-)-N-((E)-((p,beta-Dihydroxyphenethyl)amino)((2-((5-((methylamino)methyl)furfuryl)thio)ethyl)amino)methylene)methanesulfonamide
CCRIS 8408
UNII-YDB1AQ7N4L
T-593
T593 Using HRMS and NMR". Food Chem., 2019, 476, 3831-3838.
Fischer P, Wagner E. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2021, 1618, 9597-9619.