(2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide, trifluoroacetic acid CAS 1410809-37-8

(2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide, trifluoroacetic acid

纯度 97%+现货药物标准品
CAS 号1410809-37-8
分子式C20H23N3O4 C2HF3O2
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide, trifluoroacetic acid (2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide, trifluoroacetic acid CAS 1410809-37-8 结构式 Chemical Structure

产品介绍 Description

(2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide, trifluoroacetic acid（英文名 (2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide, trifluoroacetic acid，CAS 1410809-37-8）属于药物标准品。分子式 C20H23N3O4 C2HF3O2。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，(2S)-3-amino-N-hydroxy-2-(4-{4-(1R,2R)-2-(hydroxymethyl)cyclopropylbuta-1,3-diyn-1-yl}phenyl)formamido-3-methylbutanamide, trifluoroacetic acid的分子量为483.44 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 (2S)-3-amino-N-hydroxy-2-(4-{4-(1R,2R)-2-(hydroxymethyl)cyclopropylbuta-1,3-diyn-1-yl}phenyl)formamido-3-methylbutanamide, trifluoroacetic acid（(2S)-3-amino-N-hydroxy-2-(4-{4-(1R,2R)-2-(hydroxymethyl)cyclopropylbuta-1,3-diyn-1-yl}phenyl)formamido-3-methylbutanamide, trifluoroacetic aci

应用场景：(2S)-3-amino-N-hydroxy-2- (4-{4- (1R,2R)-2-(hydroxymethyl)cyclopropyl buta-1,3-diyn-1-yl}phenyl)formamido -3-methylbutanamide, trifluoroacetic acid（(2S)-3-amino-N-hydroxy-2- (4-{4- (1R,2R)-2-(hydroxymethyl)cyclopropyl buta-1,3-diyn-1-yl}phenyl)formamido -3-methylbutanamide, trifluoroacetic acid，CAS

理化性质 Physical & Chemical Properties

中文名称(2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide, trifluoroacetic acid
分子式C20H23N3O4 C2HF3O2
分子量483.44 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. 发明人王建平，周伟，罗永刚. "一种(2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide, trifluoroacetic acid的合成方法" [P]. 中国发明专利, 专利号 CN 115200544 B, 授权公告日 2017-07-06.
  2. Johansson L, Mueller T C, Nielsen H. "Method for the Synthesis of (2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide, trifluoroacetic acid" [P]. European Patent, EP 3416423 A1, 2025-10-24.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of (2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide, trifluoroacetic acid in Pharmaceutical Formulations". Chromatographia, 2023, 634, (10), 9363-9369.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of (2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide, trifluoroacetic acid as an Impurity". Environ. Sci. Technol., 2013, 854, (6), 2911-2938.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of (2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide, trifluoroacetic acid Using HRMS and NMR". J. Nat. Prod., 2013, 443, (2), 5558-5564.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate (2S)-3-amino-N-hydroxy-2-[(4-{4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diyn-1-yl}phenyl)formamido]-3-methylbutanamide, trifluoroacetic acid Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2010, 1190, (4), 9916-9928.

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