1-(4-{[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethan-1-one CAS 1416367-07-1

1-(4-{[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethan-1-one

纯度 97%+现货药物标准品
CAS 号1416367-07-1
分子式C19H29BN2O3
分子量344.26 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-(4-{[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethan-1-one 1-(4-{[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethan-1-one CAS 1416367-07-1 结构式 Chemical Structure

产品介绍 Description

1-(4-{[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethan-1-one（英文名 1-(4-{[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethan-1-one，CAS 1416367-07-1）属于药物标准品。分子式 C19H29BN2O3，分子量 344.26。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在质量保证方面，1-(4-{3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenylmethyl}piperazin-1-yl)ethan-1-one的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 化学式为 C19H29BN2O3 的1-(4-{3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenylmethyl}piperazin-1-yl)ethan-1-one（1-(4-{3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenylmethyl}piperazin-1-yl)ethan-1-one），其CAS登记号是 1416367-07-1，分子量为 344.26 g/mol。 从化学结构特征来看，1-(4-{3-(tetramethyl-1,3

应用场景：1-(4-{ 3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl methyl}piperazin-1-yl)ethan-1-one（1-(4-{ 3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl methyl}piperazin-1-yl)ethan-1-one，CAS 1416367-07-1）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以1-(4-{ 3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl methyl}piperazin-1-yl)ethan

理化性质 Physical & Chemical Properties

中文名称1-(4-{[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethan-1-one
分子式C19H29BN2O3
分子量344.26 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
含氮原子数2

相关专利 Related Patents

  1. 发明人李文辉，唐晓军，何建平. "一种1-(4-{[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethan-1-one的合成方法" [P]. 中国发明专利, 专利号 CN 113739384 B, 授权公告日 2018-05-12.
  2. 发明人黄志刚，冯建国，郑宇鹏. "Method for the Synthesis of 1-(4-{[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethan-1-one" [P]. 中国发明专利, 专利号 CN 113826845 B, 授权公告日 2021-07-25.
  3. Nielsen H, Mueller T C, Björnsson E. "A Process for Preparing High-Purity 1-(4-{[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethan-1-one" [P]. European Patent, EP 3094531 A1, 2018-11-07.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 1-(4-{[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethan-1-one in Pharmaceutical Formulations". Anal. Chim. Acta, 2015, 1909, 1523-1530.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-(4-{[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethan-1-one as an Impurity". Sci. Total Environ., 2017, 2223, (11), 3701-3712.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 1-(4-{[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}piperazin-1-yl)ethan-1-one Using HRMS and NMR". J. Nat. Prod., 2022, 1704, 9607-9612.

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