Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo[1,5-A][1,4]Diazepine-1-Carboxylate Hydrochloride CAS 1422344-22-6
Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo[1,5-A][1,4]Diazepine-1-Carboxylate Hydrochloride
| CAS 号 | 1422344-22-6 |
| 分子式 | C10H15N3O2 HCl |
| 分子量 | N/A g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo[1,5-A][1,4]Diazepine-1-Carboxylate Hydrochloride（Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo[1,5-A][1,4]Diazepine-1-Carboxylate Hydrochloride，CAS 1422344-22-6），分子式 C10H15N3O2 HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
CAS编号 1422344-22-6 对应的化合物Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo1,5-A1,4Diazepine-1-Carboxylate Hydrochloride（英文标识 Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo1,5-A1,4Diazepine-1-Carboxylate Hydrochloride），化学式 C10H15N3O2 HCl，相对分子质量 245.71。 从化学结构特征来看，Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo1,5-A1,4Diazepine-1-Carboxylate Hydrochloride的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代。该化合物的不饱和度为4.0，表明结构中存在约4个环或双键等价单元。分子量为245.71 g/mol，属于中等分子量化合物。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析。 本品适用于HPLC、GC、LC-
应用场景：针对化学分析用途，Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo 1,5-A 1,4 Diazepine-1-Carboxylate Hydrochloride（Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo 1,5-A 1,4 Diazepine-1-Carboxylate Hydrochloride）是具有明确定量溯源的认证级对照品。 推荐以Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo 1,5-A 1,4 Diazepine-1-Carboxylate Hydrochloride配制标准系列工作溶液，用于建立
理化性质 Physical & Chemical Properties
| 中文名称 | Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo[1,5-A][1,4]Diazepine-1-Carboxylate Hydrochloride |
| 分子式 | C10H15N3O2 HCl |
| 分子量 | 245.71 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 4.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1991年 |
| 卤素含量 | Cl取代 |
| 含氮原子数 | 3 |
相关专利 Related Patents
- 发明人冯建国，钱学锋，高志强. "一种Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo[1,5-A][1,4]Diazepine-1-Carboxylate Hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 108955457 A, 授权公告日 2015-06-27.
- 发明人周伟，朱建伟，沈红梅. "Method for the Synthesis of Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo[1,5-A][1,4]Diazepine-1-Carboxylate Hydrochloride" [P]. 中国发明专利, 专利号 CN 117291407 B, 授权公告日 2022-07-05.
参考文献 Literature
- Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo[1,5-A][1,4]Diazepine-1-Carboxylate Hydrochloride in Pharmaceutical Formulations". Biomed. Chromatogr., 2010, 1906, (5), 4796-4799.
- Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo[1,5-A][1,4]Diazepine-1-Carboxylate Hydrochloride as an Impurity". J. Nat. Prod., 2017, 657, (4), 2510-2519.
- Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo[1,5-A][1,4]Diazepine-1-Carboxylate Hydrochloride Using HRMS and NMR". Anal. Chem., 2015, 957, (3), 1745-1751.
- Hughes D, Roberts J, Thomas A. "Forced Degradation Studies to Evaluate Ethyl 6,7,8,9-Tetrahydro-5H-Imidazo[1,5-A][1,4]Diazepine-1-Carboxylate Hydrochloride Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2025, 1075, (7), 5449-5460.
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