4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE CAS 1429617-90-2

4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE

纯度 97%+现货药物标准品
CAS 号1429617-90-2
分子式C30H29F3N6O
分子量546.59 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE 4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE CAS 1429617-90-2 结构式 Chemical Structure

产品介绍 Description

CAS 1429617-90-2 对应的4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE（4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE）为 CATO 佳途药物标准品产品线成员。分子式 C30H29F3N6O，分子量 546.59。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

CAS编号 1429617-90-2 对应的化合物4-ETHYL-N-{3-(4-METHYLPIPERAZIN-1-YL)METHYL-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO1,5-APYRIMIDIN-6-YLETHYNYL)BENZAMIDE（英文标识 4-ETHYL-N-{3-(4-METHYLPIPERAZIN-1-YL)METHYL-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO1,5-APYRIMIDIN-6-YLETHYNYL)BENZAMIDE），化学式 C30H29F3N6O，相对分子质量 546.59。 4-ETHYL-N-{3-(4-METHYLPIPERAZIN-1-YL)METHYL-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO1,5-APYRIMIDIN-6-YLETHYNYL)BENZAMIDE（分子式 C30H29F3N6O）的化学结构中包含甾体骨架，酰胺类，含羟基，含醚键，含氟取代。在反相色谱体系中，其保留行为主要

应用场景：4-ETHYL-N-{3- (4-METHYLPIPERAZIN-1-YL)METHYL -5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO 1,5-A PYRIMIDIN-6-YLETHYNYL)BENZAMIDE（4-ETHYL-N-{3- (4-METHYLPIPERAZIN-1-YL)METHYL -5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO 1,5-A PYRIMIDIN-6-YLETHYNYL)BENZAMIDE）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以4-ETHYL-N-{3- (4-ME

理化性质 Physical & Chemical Properties

中文名称4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE
分子式C30H29F3N6O
分子量546.59 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）18.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
卤素含量F取代
含氮原子数6

相关专利 Related Patents

  1. 发明人刘建华，郑宇鹏，韩伟. "一种4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE的合成方法" [P]. 中国发明专利, 专利号 CN 117771672 B, 授权公告日 2021-06-01.
  2. 发明人孙丽萍，朱建伟，钱学锋. "Method for the Synthesis of 4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE" [P]. 中国发明专利, 专利号 CN 109676033 A, 授权公告日 2019-04-10.
  3. Nielsen H, Schröder R, Björnsson E. "A Process for Preparing High-Purity 4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE" [P]. European Patent, EP 3113585 A1, 2017-10-05.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE in Pharmaceutical Formulations". Chromatographia, 2015, 384, 9176-9206.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE as an Impurity". Food Chem., 2017, 1529, 6474-6499.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE Using HRMS and NMR". J. Chromatogr. A, 2020, 603, 2357-2365.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 4-ETHYL-N-{3-[(4-METHYLPIPERAZIN-1-YL)METHYL]-5-(TRIFLUOROMETHYL)PHENYL-3-(2-{PYRAZOLO[1,5-A]PYRIMIDIN-6-YLETHYNYL)BENZAMIDE Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2017, 993, (2), 5646-5674.

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