1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl CAS 1431963-36-8

1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl

纯度 97%+现货药物标准品
CAS 号1431963-36-8
分子式C17H20N4 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl 1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl CAS 1431963-36-8 结构式 Chemical Structure

产品介绍 Description

1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl（1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl，CAS 号 1431963-36-8）是 CATO 佳途自主生产的药物标准品，分子式 C17H20N4 HCl。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

受分子结构中含氮杂环结构，含氰基，含氯取代的影响，1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl表现为淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味）。其固体形态的物理化学属性——包括316.83 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。较高的碳氢原子比赋予该化合物良好的脂溶性，可使用正己烷或乙酸乙酯等非极性溶剂进行液-液萃取前处理。 1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl（1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl），CAS注册编号 1431963-36-8，化学分子式为 C17H20N4 HCl，分子量 316.83 g/mol。 在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（

应用场景：1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl（1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl，CAS 1431963-36-8）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl配制标准系列工作溶液，用于建立标准曲线实现

理化性质 Physical & Chemical Properties

中文名称1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl
分子式C17H20N4 HCl
分子量316.83 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
卤素含量Cl取代
含氮原子数4

相关专利 Related Patents

  1. Roberts E F, Chen K W, Davis P L. "一种1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl的合成方法" [P]. US Patent, US 10705744 B2, 2016-11-06.
  2. 发明人孙丽萍，刘建华，胡光. "Method for the Synthesis of 1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl" [P]. 中国发明专利, 专利号 CN 109588073 B, 授权公告日 2016-08-21.
  3. 发明人王建平，马晓峰，张德明. "A Process for Preparing High-Purity 1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl" [P]. 中国发明专利, 专利号 CN 108206835 A, 授权公告日 2024-05-26.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl in Pharmaceutical Formulations". J. Agric. Food Chem., 2018, 885, (5), 7849-7853.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl as an Impurity". Environ. Sci. Technol., 2022, 1049, (12), 8668-8683.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl Using HRMS and NMR". Talanta, 2021, 2385, (1), 8574-8589.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate 1-(1-ethyl-1H-pyrazol-4-yl)-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline,HCl Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2020, 717, (4), 1694-1712.

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