4-amino-1-ethyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-5-carboxamide,HCl CAS 1431963-65-3

4-amino-1-ethyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-5-carboxamide,HCl

纯度 97%+现货药物标准品
CAS 号1431963-65-3
分子式C11H16N6O HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-amino-1-ethyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-5-carboxamide,HCl 4-amino-1-ethyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-5-carboxamide,HCl CAS 1431963-65-3 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品4-amino-1-ethyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-5-carboxamide,HCl（4-amino-1-ethyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-5-carboxamide,HCl，CAS 1431963-65-3），分子式 C11H16N6O HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

4-amino-1-ethyl-N-(1-methyl-1H-pyrazol-4-yl)methyl-1H-pyrazole-5-carboxamide,HCl的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 1431963-65-3 对应的化合物4-amino-1-ethyl-N-(1-methyl-1H-pyrazol-4-yl)methyl-1H-pyrazole-5-carboxamide,HCl（英文标识 4-amino-1-ethyl-N-(1-methyl-1H-pyrazol-4-yl)methyl-1H-pyrazole-5-carboxamide,HCl），化学式 C11H16N6O HCl，相对分子质量 284.75。 4-amino-1-ethyl-N-(1-methyl-1H-pyrazol-4-yl)methyl-1H-pyrazole-5-carboxamide,HCl（C11H16N6O HCl）含有含氮杂环结构，酰胺类，含羟基，含醚

应用场景：针对化学分析用途，4-amino-1-ethyl-N- (1-methyl-1H-pyrazol-4-yl)methyl -1H-pyrazole-5-carboxamide,HCl（4-amino-1-ethyl-N- (1-methyl-1H-pyrazol-4-yl)methyl -1H-pyrazole-5-carboxamide,HCl）是具有明确定量溯源的认证级对照品。 推荐以4-amino-1-ethyl-N- (1-methyl-1H-pyrazol-4-yl)methyl -1H-pyrazole-5-carboxamide,HCl配制标准系列工作溶液，用于建立标准曲线实现

理化性质 Physical & Chemical Properties

中文名称4-amino-1-ethyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-5-carboxamide,HCl
分子式C11H16N6O HCl
分子量284.75 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
卤素含量Cl取代
含氮原子数6

相关专利 Related Patents

  1. 发明人李文辉，黄志刚，陈志强. "一种4-amino-1-ethyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-5-carboxamide,HCl的合成方法" [P]. 中国发明专利, 专利号 CN 113238037 B, 授权公告日 2019-09-27.
  2. Roberts E F, Williams B T, Davis P L. "Method for the Synthesis of 4-amino-1-ethyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-5-carboxamide,HCl" [P]. US Patent, US 11690863 B2, 2024-06-27.
  3. 发明人沈红梅，冯建国，胡光. "A Process for Preparing High-Purity 4-amino-1-ethyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-5-carboxamide,HCl" [P]. 中国发明专利, 专利号 CN 109062911 B, 授权公告日 2015-12-22.

参考文献 Literature

  1. Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of 4-amino-1-ethyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-5-carboxamide,HCl in Pharmaceutical Formulations". Anal. Methods, 2013, 2161, (12), 7991-8005.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-amino-1-ethyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-5-carboxamide,HCl as an Impurity". Anal. Chim. Acta, 2016, 1402, (11), 2685-2704.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of 4-amino-1-ethyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-5-carboxamide,HCl Using HRMS and NMR". Talanta, 2013, 2094, (2), 1022-1044.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 4-amino-1-ethyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrazole-5-carboxamide,HCl Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2011, 611, (3), 9523-9548.

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