3-methyl-1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl CAS 1431964-28-1

3-methyl-1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl

纯度 97%+现货药物标准品
CAS 号1431964-28-1
分子式C12H18N6 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-methyl-1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl 3-methyl-1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl CAS 1431964-28-1 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品3-methyl-1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl（3-methyl-1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl，CAS 1431964-28-1），分子式 C12H18N6 HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 3-methyl-1-(6,7,8,9-tetrahydro-5H-1,2,4triazolo4,3-aazepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl（3-methyl-1-(6,7,8,9-tetrahydro-5H-1,2,4triazolo4,3-aazepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl），CAS注册编号 1431964-28-1，化学分子式为 C12H18N6 HCl，分子量 282.78 g/mol。 3-methyl-1-(6,7,8,9-tetrahydro-5H-1,2,4triazolo4,3-aazepin-3-ylmethyl)-1H-pyr

应用场景：3-methyl-1-(6,7,8,9-tetrahydro-5H- 1,2,4 triazolo 4,3-a azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl（3-methyl-1-(6,7,8,9-tetrahydro-5H- 1,2,4 triazolo 4,3-a azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl，CAS 1431964-28-1）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以3-methyl-1-(6,7,8,9-tetrahydro-5H- 1,2,4 triazolo 4,3-a az

理化性质 Physical & Chemical Properties

中文名称3-methyl-1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl
分子式C12H18N6 HCl
分子量282.78 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
卤素含量Cl取代
含氮原子数6

相关专利 Related Patents

  1. 发明人周伟，何建平，郭海燕. "一种3-methyl-1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl的合成方法" [P]. 中国发明专利, 专利号 CN 116477759 B, 授权公告日 2015-07-22.
  2. 发明人朱建伟，周伟，郭海燕. "Method for the Synthesis of 3-methyl-1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl" [P]. 中国发明专利, 专利号 CN 116215713 B, 授权公告日 2018-02-17.
  3. Brown S R, Williams B T, Roberts E F. "A Process for Preparing High-Purity 3-methyl-1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl" [P]. US Patent, US 9898047 B2, 2023-11-28.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 3-methyl-1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl in Pharmaceutical Formulations". Food Chem., 2013, 1448, (12), 7286-7310.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-methyl-1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl as an Impurity". Rapid Commun. Mass Spectrom., 2022, 1502, 8626-8644.
  3. Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 3-methyl-1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl Using HRMS and NMR". Chemosphere, 2019, 1778, 3865-3888.
  4. Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate 3-methyl-1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)-1H-pyrazol-4-amine,HCl Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2010, 1647, 4066-4082.

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