5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid CAS 1431970-09-0

5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1431970-09-0
分子式C11H16N2O3 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid 5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid CAS 1431970-09-0 结构式 Chemical Structure

产品介绍 Description

CAS 1431970-09-0 对应的5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid（5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid）为 CATO 佳途药物标准品产品线成员。分子式 C11H16N2O3 HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid的分子量为260.72 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C11H16N2O3 HCl 的5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid（5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid），其CAS登记号是 1431970-09-0，分子量为 260.72 g/mol。 5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid（C11H16N2O3 HCl）含有含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代。具有较强的吸湿性，卤素取代增加了化合物的密度和沸点，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。由于结构中存在共轭发色团，该化合物在200-4

应用场景：5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid（5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在

理化性质 Physical & Chemical Properties

中文名称5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid
分子式C11H16N2O3 HCl
分子量260.72 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人林芳，马晓峰，孙丽萍. "一种5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 116634433 B, 授权公告日 2020-04-01.
  2. Roberts E F, Johnson M A, Lee S K. "Method for the Synthesis of 5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid" [P]. US Patent, US 10754491 B2, 2022-06-11.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid in Pharmaceutical Formulations". Chromatographia, 2014, 2161, 7095-7099.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid as an Impurity". Talanta, 2012, 182, 5035-5058.
  3. Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of 5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid Using HRMS and NMR". Phytochemistry, 2010, 2090, (1), 6246-6273.
  4. Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate 5-methyl-4-(piperidin-1-ylmethyl)isoxazole-3-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2025, 1769, 7812-7834.

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