2-Oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1,2-dihydropyrimidine-5-carboxylic acid CAS 1439902-37-0

2-Oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1,2-dihydropyrimidine-5-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1439902-37-0
分子式C11H14N2O4
分子量238.24 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-Oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1,2-dihydropyrimidine-5-carboxylic acid 2-Oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1,2-dihydropyrimidine-5-carboxylic acid CAS 1439902-37-0 结构式 Chemical Structure

产品介绍 Description

CAS 1439902-37-0 对应的2-Oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1,2-dihydropyrimidine-5-carboxylic acid（2-Oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1,2-dihydropyrimidine-5-carboxylic acid）为 CATO 佳途药物标准品产品线成员。分子式 C11H14N2O4，分子量 238.24。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 2-Oxo-1-(tetrahydro-2H-pyran-4-yl)methyl-1,2-dihydropyrimidine-5-carboxylic acid（2-Oxo-1-(tetrahydro-2H-pyran-4-yl)methyl-1,2-dihydropyrimidine-5-carboxylic acid），CAS注册编号 1439902-37-0，化学分子式为 C11H14N2O4，分子量 238.24 g/mol。 2-Oxo-1-(tetrahydro-2H-pyran-4-yl)methyl-1,2-dihydropyrimidine-5-carboxylic acid（C11H14N2O4）含有氨基酸衍生物，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。由于结构中存在共轭发色团，该化合物在200-400 n

应用场景：2-Oxo-1- (tetrahydro-2H-pyran-4-yl)methyl -1,2-dihydropyrimidine-5-carboxylic acid（2-Oxo-1- (tetrahydro-2H-pyran-4-yl)methyl -1,2-dihydropyrimidine-5-carboxylic acid，CAS 1439902-37-0）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以2-Oxo-1- (tetrahydro-2H-pyran-4-yl)methyl -1,2-dihydropyrimidine-5-carboxylic acid配制标准系列

理化性质 Physical & Chemical Properties

中文名称2-Oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1,2-dihydropyrimidine-5-carboxylic acid
分子式C11H14N2O4
分子量238.24 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
含氮原子数2

相关专利 Related Patents

  1. 发明人黄志刚，钱学锋，王建平. "一种2-Oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1,2-dihydropyrimidine-5-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 109638826 B, 授权公告日 2017-07-10.
  2. 发明人钱学锋，韩伟，唐晓军. "Method for the Synthesis of 2-Oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1,2-dihydropyrimidine-5-carboxylic acid" [P]. 中国发明专利, 专利号 CN 113301295 A, 授权公告日 2018-10-18.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 2-Oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1,2-dihydropyrimidine-5-carboxylic acid in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2025, 88, 4893-4905.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-Oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1,2-dihydropyrimidine-5-carboxylic acid as an Impurity". J. Sep. Sci., 2020, 779, (4), 6589-6618.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 2-Oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1,2-dihydropyrimidine-5-carboxylic acid Using HRMS and NMR". J. Nat. Prod., 2010, 1398, 6077-6100.
  4. Kim S H, Park J Y. "Forced Degradation Studies to Evaluate 2-Oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-1,2-dihydropyrimidine-5-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2022, 1104, 7931-7954.

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