4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-5-methylfuran-2-carboxylic acid CAS 1455991-37-3

4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-5-methylfuran-2-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1455991-37-3
分子式C15H11NO5
分子量285.25 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-5-methylfuran-2-carboxylic acid 4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-5-methylfuran-2-carboxylic acid CAS 1455991-37-3 结构式 Chemical Structure

产品介绍 Description

CAS 1455991-37-3 对应的4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-5-methylfuran-2-carboxylic acid（4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-5-methylfuran-2-carboxylic acid）为 CATO 佳途药物标准品产品线成员。分子式 C15H11NO5，分子量 285.25。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl-5-methylfuran-2-carboxylic acid在内的目标物的控制。 CAS编号 1455991-37-3 对应的化合物4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl-5-methylfuran-2-carboxylic acid（英文标识 4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl-5-methylfuran-2-carboxylic acid），化学式 C15H11NO5，相对分子质量 285.25。 4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl-5-methylfuran-2-carboxylic acid（分子式 C15H11NO5）的化学结构中包含黄酮骨架，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状

应用场景：4- (1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl -5-methylfuran-2-carboxylic acid（4- (1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl -5-methylfuran-2-carboxylic acid，CAS 1455991-37-3）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以4- (1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl -5-methylfuran-2-carboxylic acid配制标准系列

理化性质 Physical & Chemical Properties

中文名称4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-5-methylfuran-2-carboxylic acid
分子式C15H11NO5
分子量285.25 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1992年
含氮原子数1

相关专利 Related Patents

  1. Roberts E F, Kumar R, Mueller T. "一种4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-5-methylfuran-2-carboxylic acid的合成方法" [P]. US Patent, US 10809369 B2, 2022-12-25.
  2. Björnsson E, Nowak P, Rossi M. "Method for the Synthesis of 4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-5-methylfuran-2-carboxylic acid" [P]. European Patent, EP 3602190 A1, 2016-07-24.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-5-methylfuran-2-carboxylic acid in Pharmaceutical Formulations". Sci. Total Environ., 2019, 877, 5705-5717.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-5-methylfuran-2-carboxylic acid as an Impurity". Biomed. Chromatogr., 2020, 2299, 2652-2677.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-5-methylfuran-2-carboxylic acid Using HRMS and NMR". Phytochemistry, 2024, 1269, (8), 763-770.
  4. Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate 4-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]-5-methylfuran-2-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2017, 1347, 6236-6240.

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