1-[2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)-3-methylphenyl]-4-methyl-1,4-dihydro-5H-tetrazol-5-one: metyltetraprole CAS 1472649-01-6

Metyltetraprole

纯度 97%+现货药物标准品
CAS 号1472649-01-6
分子式C19H17ClN6O2
分子量396.83 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-[2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)-3-methylphenyl]-4-methyl-1,4-dihydro-5H-tetrazol-5-one: metyltetraprole Metyltetraprole CAS 1472649-01-6 结构式 Chemical Structure

产品介绍 Description

1-[2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)-3-methylphenyl]-4-methyl-1,4-dihydro-5H-tetrazol-5-one: metyltetraprole（Metyltetraprole）是药物分析与质量控制领域常用的药物标准品，CAS 号 1472649-01-6。分子式 C19H17ClN6O2，分子量 396.83。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

1-2-({1-(4-chlorophenyl)-1H-pyrazol-3-yloxy}methyl)-3-methylphenyl-4-methyl-1,4-dihydro-5H-tetrazol-5-one: metyltetraprole（C19H17ClN6O2）含有甾体骨架，酰胺类，含羟基，含醚键，含氯取代。具有较强的吸湿性，卤素取代增加了化合物的密度和沸点，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析。 化学式为 C19H17ClN6O2 的1-2-({1-(4-chlorophenyl)-1H-pyrazol-3-yloxy}methyl)-3-methylphenyl-4-methyl-1,4-dihydro-5H-tetrazol-5-one: metyltetraprole（Metyltetraprole），其CAS登记号是 1472649-01-6，分子量为 396.83 g/mol。 在定

应用场景：针对化学分析用途，1- 2-({ 1-(4-chlorophenyl)-1H-pyrazol-3-yl oxy}methyl)-3-methylphenyl -4-methyl-1,4-dihydro-5H-tetrazol-5-one: metyltetraprole（Metyltetraprole）是具有明确定量溯源的认证级对照品。 推荐以1- 2-({ 1-(4-chlorophenyl)-1H-pyrazol-3-yl oxy}methyl)-3-methylphenyl -4-methyl-1,4-dihydro-5H-tetrazol-5-one: metyltetraprole

理化性质 Physical & Chemical Properties

中文名称1-[2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)-3-methylphenyl]-4-methyl-1,4-dihydro-5H-tetrazol-5-one: metyltetraprole
分子式C19H17ClN6O2
分子量396.83 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）14.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1992年
卤素含量Cl取代
含氮原子数6

相关专利 Related Patents

  1. 发明人钱学锋，郭海燕，王建平. "一种1-[2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)-3-methylphenyl]-4-methyl-1,4-dihydro-5H-tetrazol-5-one: metyltetraprole的合成方法" [P]. 中国发明专利, 专利号 CN 114079752 B, 授权公告日 2016-05-15.
  2. Nowak P, Sørensen M, Björnsson E. "Method for the Synthesis of Metyltetraprole" [P]. European Patent, EP 3034875 A1, 2022-09-13.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 1-[2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)-3-methylphenyl]-4-methyl-1,4-dihydro-5H-tetrazol-5-one: metyltetraprole in Pharmaceutical Formulations". Anal. Chem., 2010, 2054, (10), 8652-8680.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-[2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)-3-methylphenyl]-4-methyl-1,4-dihydro-5H-tetrazol-5-one: metyltetraprole as an Impurity". Rapid Commun. Mass Spectrom., 2020, 270, (8), 1603-1630.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of Metyltetraprole Using HRMS and NMR". Chemosphere, 2023, 983, 3129-3134.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 1-[2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)-3-methylphenyl]-4-methyl-1,4-dihydro-5H-tetrazol-5-one: metyltetraprole Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2018, 1492, (5), 265-270.

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