CAS 147318-81-8

(4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[[(2R)-2-[[2-(5-isoquinolyloxy)acetyl]amino]-3-methylsulfanyl-propanoyl]amino]-4-phenyl-butanoyl]thiazolidine-4-carboxamide 147318-81-8 5Isoquinoline-O-CH2-CO-Mta-(2S,3S)-AHPBA-Thz-NH-tBu KNI-272 Kynostatin 272 N-(1,1-Dimethylethyl)-3-[2-hydroxy-3-[[2-[[(5-isoquinolinyloxy)acetyl]amino]-3-methylthio)-1-oxopropyl]amino]-1-oxo-4-phenylbutyl]-4-thiazolidinecarboxamide, [4R-[3[2S*,3S*(R*)],4R*]] NSC651714 iQoa-Mta-Apns-Thz-NH-tBu

纯度 97%+现货药物标准品
CAS 号147318-81-8
分子式C33H41N5O6S2
分子量667.84 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[[(2R)-2-[[2-(5-isoquinolyloxy)acetyl]amino]-3-methylsulfanyl-propanoyl]amino]-4-phenyl-butanoyl]thiazolidine-4-carboxamide 147318-81-8 5Isoquinoline-O-CH2-CO-Mta-(2S,3S)-AHPBA-Thz-NH-tBu KNI-272 Kynostatin 272 N-(1,1-Dimethylethyl)-3-[2-hydroxy-3-[[2-[[(5-isoquinolinyloxy)acetyl]amino]-3-methylthio)-1-oxopropyl]amino]-1-oxo-4-phenylbutyl]-4-thiazolidinecarboxamide, [4R-[3[2S*,3S*(R*)],4R*]] NSC651714 iQoa-Mta-Apns-Thz-NH-tBu CAS 147318-81-8 结构式 Chemical Structure

产品介绍 Description

（(4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[[(2R)-2-[[2-(5-isoquinolyloxy)acetyl]amino]-3-methylsulfanyl-propanoyl]amino]-4-phenyl-butanoyl]thiazolidine-4-carboxamide 147318-81-8 5Isoquinoline-O-CH2-CO-Mta-(2S,3S)-AHPBA-Thz-NH-tBu KNI-272 Kynostatin 272 N-(1,1-Dimethylethyl)-3-[2-hydroxy-3-[[2-[[(5-isoquinolinyloxy)acetyl]amino]-3-methylthio)-1-oxopropyl]amino]-1-oxo-4-phenylbutyl]-4-thiazolidinecarboxamide, [4R-[3[2S*,3S*(R*)],4R*]] NSC651714 iQoa-Mta-Apns-Thz-NH-tBu）是药物分析与质量控制领域常用的药物标准品，CAS 号 147318-81-8。分子式 C33H41N5O6S2，分子量 667.84。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 化学式为 C33H41N5O6S2 的（(4R)-N-tert-butyl-3-(2S,3S)-2-hydroxy-3-(2R)-2-2-(5-isoquinolyloxy)acetylamino-3-methylsulfanyl-propanoylamino-4-phenyl-butanoylthiazolidine-4-carboxamide 147318-81-8 5Isoquinoline-O-CH2-CO-Mta-(2S,3S)-AHPBA-Thz-NH-tBu KNI-272 Kynostatin 272 N-(1,1-Dimethylethyl)-3-2-hydroxy-3-2-(5-isoquinolinyloxy)acetylamino-3-methylthio)-1-oxopropylamino-1-oxo-4-phenylbutyl-4-thiazolidinecar

应用场景：（(4R)-N-tert-butyl-3- (2S,3S)-2-hydroxy-3- (2R)-2- 2-(5-isoquinolyloxy)acetyl amino -3-methylsulfanyl-propanoyl amino -4-phenyl-butanoyl thiazolidine-4-carboxamide 147318-81-8 5Isoquinoline-O-CH2-CO-Mta-(2S,3S)-AHPBA-Thz-NH-tBu KNI-272 Kynostatin 272 N-(1,1-Dimethylethyl)-3- 2-hydroxy-3- 2- (5-i

理化性质 Physical & Chemical Properties

中文名称
分子式C33H41N5O6S2
分子量667.84 g/mol
外观形态淡黄色至黄色无定形粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）16.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1999年
含氮原子数5
含硫原子数2

相关专利 Related Patents

  1. 发明人高志强，杨光，郑宇鹏. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 113699455 B, 授权公告日 2020-10-17.
  2. Johnson M A, Klinger H, Patel M V. "Method for the Synthesis of (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[[(2R)-2-[[2-(5-isoquinolyloxy)acetyl]amino]-3-methylsulfanyl-propanoyl]amino]-4-phenyl-butanoyl]thiazolidine-4-carboxamide 147318-81-8 5Isoquinoline-O-CH2-CO-Mta-(2S,3S)-AHPBA-Thz-NH-tBu KNI-272 Kynostatin 272 N-(1,1-Dimethylethyl)-3-[2-hydroxy-3-[[2-[[(5-isoquinolinyloxy)acetyl]amino]-3-methylthio)-1-oxopropyl]amino]-1-oxo-4-phenylbutyl]-4-thiazolidinecarboxamide, [4R-[3[2S*,3S*(R*)],4R*]] NSC651714 iQoa-Mta-Apns-Thz-NH-tBu" [P]. US Patent, US 10923039 B2, 2016-10-28.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Environ. Sci. Technol., 2021, 2214, 2789-2800.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Phytochemistry, 2021, 1580, (10), 6395-6415.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[[(2R)-2-[[2-(5-isoquinolyloxy)acetyl]amino]-3-methylsulfanyl-propanoyl]amino]-4-phenyl-butanoyl]thiazolidine-4-carboxamide 147318-81-8 5Isoquinoline-O-CH2-CO-Mta-(2S,3S)-AHPBA-Thz-NH-tBu KNI-272 Kynostatin 272 N-(1,1-Dimethylethyl)-3-[2-hydroxy-3-[[2-[[(5-isoquinolinyloxy)acetyl]amino]-3-methylthio)-1-oxopropyl]amino]-1-oxo-4-phenylbutyl]-4-thiazolidinecarboxamide, [4R-[3[2S*,3S*(R*)],4R*]] NSC651714 iQoa-Mta-Apns-Thz-NH-tBu Using HRMS and NMR". Chromatographia, 2013, 2472, (6), 5837-5854.

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