methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate CAS 147330-26-5

methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate

纯度 97%+现货药物标准品
CAS 号147330-26-5
分子式C11H15NO3
分子量209.24 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate CAS 147330-26-5 结构式 Chemical Structure

产品介绍 Description

CAS 147330-26-5 对应的methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate（methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C11H15NO3，分子量 209.24。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate在内的目标物的控制。 化学式为 C11H15NO3 的methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate（methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate），其CAS登记号是 147330-26-5，分子量为 209.24 g/mol。 methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate（C11H15NO3）含有氨基酸衍生物，酰胺类，含羟基，含醚键。具有较强的吸湿性，较高的碳氢比使其脂溶性较好，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/M

应用场景：methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate（methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议：

理化性质 Physical & Chemical Properties

中文名称methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate
分子式C11H15NO3
分子量209.24 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1999年
含氮原子数1

相关专利 Related Patents

  1. 发明人周伟，郭海燕，朱建伟. "一种methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 115953360 B, 授权公告日 2022-07-27.
  2. Martínez F, Björnsson E, Johansson L. "Method for the Synthesis of methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate" [P]. European Patent, EP 3618365 A1, 2015-08-21.
  3. Nowak P, Schröder R, Jørgensen K. "A Process for Preparing High-Purity methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate" [P]. European Patent, EP 3206978 A1, 2023-08-26.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2020, 308, 6749-6757.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate as an Impurity". Molecules, 2012, 2456, 4553-4560.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate Using HRMS and NMR". J. Sep. Sci., 2010, 1584, (11), 9689-9701.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate methyl 6-methyl-4-oxo-2-propyl-1,4-dihydropyridine-3-carboxylate Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2022, 2413, (12), 4439-4467.

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