6,8,25,27-四氢-双萘并[2',3':6,7]吲哚并[2,3-c:2',3'-c']二奈并[2,3-i:2',3'-i']苯并1,2-a:5,4-a']双咔唑-5,7,9,14,19,24,26,28,33,38-十酮, CAS 14999-97-4

Bisnaphth[2',3':6,7]indolo[2,3-c:2',3'-c']dinaphtho[2,3-i:2',3'-i']benzo[1,2-a:5,4-a']dicarbazole-5,7,9,14,19,24,26,28,33,38-decone, 6,8,25,27-tetrahydro-

纯度 97%+现货药物标准品
CAS 号14999-97-4
分子式C70H28N4O10
分子量1084.99 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

6,8,25,27-四氢-双萘并[2',3':6,7]吲哚并[2,3-c:2',3'-c']二奈并[2,3-i:2',3'-i']苯并1,2-a:5,4-a']双咔唑-5,7,9,14,19,24,26,28,33,38-十酮, Bisnaphth[2',3':6,7]indolo[2,3-c:2',3'-c']dinaphtho[2,3-i:2',3'-i']benzo[1,2-a:5,4-a']dicarbazole-5,7,9,14,19,24,26,28,33,38-decone, 6,8,25,27-tetrahydro- CAS 14999-97-4 结构式 Chemical Structure

产品介绍 Description

6,8,25,27-四氢-双萘并[2',3':6,7]吲哚并[2,3-c:2',3'-c']二奈并[2,3-i:2',3'-i']苯并1,2-a:5,4-a']双咔唑-5,7,9,14,19,24,26,28,33,38-十酮,（英文名 Bisnaphth[2',3':6,7]indolo[2,3-c:2',3'-c']dinaphtho[2,3-i:2',3'-i']benzo[1,2-a:5,4-a']dicarbazole-5,7,9,14,19,24,26,28,33,38-decone, 6,8,25,27-tetrahydro-，CAS 14999-97-4）属于药物标准品。分子式 C70H28N4O10，分子量 1084.99。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键的影响，6,8,25,27-四氢-双萘并2',3':6,7吲哚并2,3-c:2',3'-c'二奈并2,3-i:2',3'-i'苯并1,2-a:5,4-a'双咔唑-5,7,9,14,19,24,26,28,33,38-十酮,表现为淡黄色至黄色无定形粉末。其固体形态的物理化学属性——包括1084.99 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 CAS编号 14999-97-4 对应的化合物6,8,25,27-四氢-双萘并2',3':6,7吲哚并2,3-c:2',3'-c'二奈并2,3-i:2',3'-i'苯并1,2-a:5,4-a'双咔唑-5,7,9,14,19,24,26,28,33,38-十酮,（英文标识 Bisnaphth2',3':6,7indolo2,3-c:2',3'-c'dinaphtho2,3-i:2',3'-i'benzo1,2-a:5,4-a'dica

应用场景：从实际应用出发，6,8,25,27-四氢-双萘并 2',3':6,7 吲哚并 2,3-c:2',3'-c' 二奈并 2,3-i:2',3'-i' 苯并1,2-a:5,4-a' 双咔唑-5,7,9,14,19,24,26,28,33,38-十酮,（CAS 14999-97-4）在化学分析中作为关键的基准对照物质。 推荐以6,8,25,27-四氢-双萘并 2',3':6,7 吲哚并 2,3-c:2',3'-c' 二奈并 2,3-i:2',3'-i' 苯并1,2-a:5,4-a' 双咔唑-5,7,9,14,19,24,26,28,33,38-十酮,配制标准系列工作溶液，用于建立标准曲线实现外标法定

理化性质 Physical & Chemical Properties

中文名称6,8,25,27-四氢-双萘并[2',3':6,7]吲哚并[2,3-c:2',3'-c']二奈并[2,3-i:2',3'-i']苯并1,2-a:5,4-a']双咔唑-5,7,9,14,19,24,26,28,33,38-十酮,
分子式C70H28N4O10
分子量1084.99 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）59.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1961年
含氮原子数4

相关专利 Related Patents

  1. Yamamoto T, Davis P L, Klinger H. "一种6,8,25,27-四氢-双萘并[2',3':6,7]吲哚并[2,3-c:2',3'-c']二奈并[2,3-i:2',3'-i']苯并1,2-a:5,4-a']双咔唑-5,7,9,14,19,24,26,28,33,38-十酮,的合成方法" [P]. US Patent, US 11222931 B2, 2018-06-04.
  2. Lee S K, Yamamoto T, Mueller T. "Method for the Synthesis of Bisnaphth[2',3':6,7]indolo[2,3-c:2',3'-c']dinaphtho[2,3-i:2',3'-i']benzo[1,2-a:5,4-a']dicarbazole-5,7,9,14,19,24,26,28,33,38-decone, 6,8,25,27-tetrahydro-" [P]. US Patent, US 10601838 B2, 2023-05-26.
  3. 发明人孙丽萍，陈志强，徐明华. "A Process for Preparing High-Purity Bisnaphth[2',3':6,7]indolo[2,3-c:2',3'-c']dinaphtho[2,3-i:2',3'-i']benzo[1,2-a:5,4-a']dicarbazole-5,7,9,14,19,24,26,28,33,38-decone, 6,8,25,27-tetrahydro-" [P]. 中国发明专利, 专利号 CN 114904172 A, 授权公告日 2015-07-05.

参考文献 Literature

  1. Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of 6,8,25,27-四氢-双萘并[2',3':6,7]吲哚并[2,3-c:2',3'-c']二奈并[2,3-i:2',3'-i']苯并1,2-a:5,4-a']双咔唑-5,7,9,14,19,24,26,28,33,38-十酮, in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2018, 690, (6), 7387-7415.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 6,8,25,27-四氢-双萘并[2',3':6,7]吲哚并[2,3-c:2',3'-c']二奈并[2,3-i:2',3'-i']苯并1,2-a:5,4-a']双咔唑-5,7,9,14,19,24,26,28,33,38-十酮, as an Impurity". Chromatographia, 2012, 788, (10), 8791-8809.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of Bisnaphth[2',3':6,7]indolo[2,3-c:2',3'-c']dinaphtho[2,3-i:2',3'-i']benzo[1,2-a:5,4-a']dicarbazole-5,7,9,14,19,24,26,28,33,38-decone, 6,8,25,27-tetrahydro- Using HRMS and NMR". Biomed. Chromatogr., 2011, 1974, 7861-7868.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate 6,8,25,27-四氢-双萘并[2',3':6,7]吲哚并[2,3-c:2',3'-c']二奈并[2,3-i:2',3'-i']苯并1,2-a:5,4-a']双咔唑-5,7,9,14,19,24,26,28,33,38-十酮, Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2019, 622, 2262-2284.

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